Ann McKee, MD Publications

McKee Publication List April 8, 2024

1. McKee AC, Winkelman MD, Banker BQ: Central pontine myelinolysis in severely burned patients: relationship to serum hyperosmolality. Neurology 1988; 38: 1211-7

2. Ogilvy CS, McKee AC, Newman NJ, Donnelly SM, Kiwak KJ: Embolism of cerebral tissue to the lungs: a report of 2 cases and review of the literature. Neurosurgery, 1988; 23: 511-6

3. McKee AC, Kowall NW, Kosik KS: Microtubular reorganization and dendritic growth response in Alzheimer’s disease. Annals of Neurology, 1989; 26:652-9

4. McKee AC, Kowall NW, Kosik KS: Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II Ca/calmodulin-dependent protein kinase. J Neuropathol Exp Neurol, 1990; 49: 49-63

5. Newman NJ, Bell IR, McKee AC: Paraneoplastic limbic encephalitis: neuropsychiatric presentation. Biol Psych, 1990; 27: 529-42

6. Thulborn KR, Sorensen AG, Kowall NW, McKee AC, Lai A, McKinstry RC, Moore J, Rosen BR, Brady TJ: Biochemical correlation of the magnetic resonance appearance of experimentally induced cerebral hemorrhage in the rat. Amer J Neuroradiology, 1990; 11: 291- 7

7. McKee AC, Levine D, Kowall NW, Richardson EP: Peduncular hallucinosis associated with isolated infarction of medial substantia nigra pars reticulata. Annals of Neurology, 1990; 27: 500-4

8. McKee AC, Kosik KS, Kowall NW: Neuritic pathology and dementia in Alzheimer’s disease. Annals of Neurology, 1991; 30: 156-65

9. Mikulis DJ, Ogilvy CS, McKee AC, Davis KR, Ojemann RG: Serial MR imaging in a case of distal spinal cord and conus medullaris infarction due to fibrocartilagenous emboli. Amer J Neuroradiology, 1992;13:155-60

10. Kowall NW, McKee AC, Yankner BA, Beal MF: In vivo neurotoxicity of beta amyloid [ß (1-40)] and the ß (25-35) fragment. Neurobiol Aging, 1992; 13:537-542

11. Markesbery W, Kosik KS, Kowall NW, McKee AC: Morphometric image analysis of neuropil threads in Alzheimer’s disease. Neurobiol Aging, 1993; 14 (4): 303-7

12. Nihei K, McKee AC, Kowall NW. Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol, 1993; 86 (1): 55-64

13. Hauw JJ, Daniel SE, Dickson D, Horoupian DS, Jellinger K, Lantos PL, McKee AC, Tabaton M, Litvan I. Preliminary NINDS Neuropathological Criteria for Steele-Richardson- Olszewski Syndrome (Progressive Supranuclear Palsy). Neurology; 1994, 44(11): 2015-9

14. Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, McKee AC, Beal MF, Graham BH, Wallace DC. Marked changes in mitochondrial DNA deletion levels in Alzheimer’s brains. Genomics 1994 23 (2): 471-6

15. VonSattel JP, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M, Gusella J, Landwehrmeyer B, Bird ED, Richardson EP, Hedley-Whyte ET. An improved method to prepare human brains for research. J Neurol Exp Neuropathol, 1995, 54: 42-57

16. Farrer LA, Abraham CR, Volicer L, Foley EJ, Kowall NW, McKee AC, Wells JM. Allele E4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. Exp Neurol, 1995, 136, 162-170

17. Litvan I, Agid Y, Jankovic J, Goetz C, Brandel JP, Lai EC, Wenning G, D’Olhaberriague L, Verny M, Chaudhuri KR, McKee A, Jellinger K, Bartko JJ, Mangone CA, Pearce RKB. Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele- Richardson-Olszewski). Neurology 1996, 46: 922-930

18. Litvan I, Hauw JJ, Bartko JJ, Lantos PL, Daniel SE, Horoupian DS, McKee AC, Dickson D, Bancher C, Tabaton M, Jellinger K, Anderson DW. Accuracy of the neuropathological diagnosis of neurodegenerative disorders with extrapyramidal features. J. Neuropath Exp Neurolology 1996, 55, 97-105

19. Litvan I, DeLeo JM, Hauw JJ, Daniel SE, Jellinger K, McKee A, Dickson D, Horoupian DS, Lantos PL, Tabaton M. What Can Artificial Networks Teach Us About Neurodegenerative Disorders with Extrapyramidal Features? Brain 1996, 119: 831-839

20. Litvan I, Agid Y. Goetz C, Jankovic J, Wenning G, Brandel JP, Lai EC, Verny M, Chaudhuri KR, McKee A, Jellinger K, Pearce RKB, Bartko JJ. Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathological study. Neurology 1997, 48: 119-125

21. Litvan I, Goetz CG, Jankovic J, Wenning GK, Booth V, Bartko JJ, McKee A, Jellinger K, Lai EC, Brandel J-P, Verny M, Chaudhuri R, Pearce RKB, Agid Y. What is the accuracy of the clinical diagnosis of Multiple System Atrophy? A clinicopathological study. Arch Neurol 1997, 54;937-944

22. Litvan I, Campbell G, Mangone CA, Verny M, McKee A, Chaudhuri KR, Jellinger K, Pearce RKB, D’Olhaberriague L. Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study. Brain 1997, 120:65-74

23. Litvan I, Agid Y, Sastrj N, Jankovic J, Wenning GK, Goetz CG, Verny M, Brandel J-P, Jellinger K, Chaudhuri R, McKee A, Lai EC, Pearce RKB, Bartko JJ. What are the obstacles for an accurate diagnosis of Pick’s disease? A clinicopathological study. Neurology 1997, 49: 62-69.

24. McKee AC, Kowall NW, Schumacher JS, Beal MF. The neurotoxicity of amyloid beta protein in aged primates. Amyloid, 1998, 5: 1-9

25. Litvan I, Booth V, Wenning GK, Bartko JJ, Goetz CG, McKee A, Jankovic J, Jellinger K, Lai EC, Brandel JP, Verny M, Chaudhuri KR, Pearce RKB, Agid Y. Retrospective application of a set of clinical diagnostic criteria for the diagnosis of multiple system atrophy. J Neural Transm 1998 105: 217-228

26. Litvan I, MacIntyre A, Goetz CG, Wenning GK, Jellinger K, Verny M, Bartko JJ, Jankovic J, McKee A, Brandel JP, Chaudhuri KR, Lai EC, D’Olhaberriague L, Pearce RKB, Agid Y. Accuracy of the clinical diagnoses of Lewy Body disease, Parkinson disease, and Dementia with Lewy Bodies. A clinicopathological study. Arch Neurol 1998, 5: 969-978

27. Wenning GK, Litvan I, MacIntyre A, Goetz CG, Wenning Jellinger K, Verny M, Bartko JJ, Jankovic J, McKee A, Brandel JP, Chaudhuri KR, Lai EC, D’Olhaberriague L, Pearce RKB, Agid Natural history and survival of 14 patients with corticobasal degeneration confirmed at post-mortem examination. J Neurol Neurosurg Psych 1998 64: 184-9

28. McKee A. Neuropathology and brain banking: basic science methods. . Alzheimer Dis Assoc Dis. 1999, 13, suppl 1: S39-S44

29. Litvan I, McKee, A. Clinicopathologic Case Report. J Neuropsych Clin Neurosci. 1999, 11:107- 112

30. Wenning GK, Ebersbach G, Verny M, Chaudhuri KR, Jellinger K, McKee A, Poewe W, Litvan I. Progression of falls in postmortem confirmed parikinsonian disorders. Mov Dis, 1999, 14: 947-50

31. Volicer L, Wells JM, McKee AC, Kowall NW. Enhanced inhibition of free radical-induced deoxyribose breakdown by Alzheimer brain homogenates. Neurosci Lett 1999; 270:169-72.

32. Hanlon EB, Itzkan I, Dasari R, Feld MS, Ferrante RJ, McKee AC, Lathi D, Kowall NW. Near-infrared fluorescence spectroscopy detects Alzheimer’s disease in vitro. Photochem and Photobiol, 1999, 70: 236-242

33. Litvan I, Grimes DA, Lang AE, Jankovic J, McKee A, Verny M, Jellinger K, Chaudhuri KR, Pearce RKB. Clinical features differentiating patients with postmortem progressive supranuclear palsy and corticobasal degeneration. J Neurol, 1999;246 [suppl 2]: II/1-II/5

34. Chung TF, Sipe JD, McKee A, Fine RE, Scheiber BM, Liang JS, Johnson RJ. Serum amyloid A in Alzheimer’s disease brain is predominantly localized to myelin sheaths and axonal membrane. Amyloid 2000; 7: 105-11.

35. Kowall NW, Hantaye P, Brouillet E, Beal MF, McKee AC, Ferrante RF. MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons. Neuroreport 2000, 11:1-3
36. Muller J, Wenning GK, Jellinger K, McKee A, Poewe W, Litvan I. Progression of Hoehn and Yahr stages in Parkinsonian disorders: a clinicopathologic study. Neurology. 2000 Sep 26; 55(6): 888-9.

37. Muller J, Wenning G, Verny M, McKee A, Chaudhuri R, Poewe W, Litvan I. Progression of dysarthria and dysphagia in post-mortem-confirmed Parkinsonian disorders. Arch Neurol 2001; 58: 259-264

38. Volicer L, McKee AC, Hewitt S. Dementia. Neurology Clinics 2001, 19: 867- 885.

39. Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R, Volicer L. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psych 2001; 5894): 353-60

40. Georgopoulos S, McKee A, Kan HY, Zannis VI. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry. 2002 Jul 30; 41(30): 9293-301

41. Gao W, Eisenhauer PB, Conn K, Lynch JA, Wells JM, Ullman MD, McKee A, Thatte HS, Fine RE. (2004) Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells. Neurosci Lett. 371 (1): 6- 11

42. Conn K, Gao W, McKee A, Lan MS, Ullman MD, Eisenhauer PB, Fine R and Wells JM. (2004) Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson’s diease and Lewy Body Pathology, Brain Res. 1022 (1-2):164-72

43. Yip AG, McKee AC, Wells J, Green RC, Young H, Cupples A, Farrer LA. ApoE, vascular pathology, and the AD brain. Neurology, 2005; 65:259-265

44. Wolozin B, Manger J, Bryant R, Cordy J, Green RC, McKee A. Re-assessing the relationship between cholesterol, statins and Alzheimer’s disease. Acta Neurol Scand Suppl. 2006; 185:63-70

45. Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells J, McKee A, Ullman D, Fine RE. Insulin degrading enzyme is localized predominantly in the cell surface of polarized and unpolarized human cerebrovascular endothelial cultures. J Neurosci Res. 2006 May 15; 83(7): 1262-70

46. Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Krapko K. Mitochondrial DNA deletions are abundant and cause functional impairment of select human substantia nigra neurons. Nature Genetics, 2006 May; 38(5): 518-20

47. McKee, AC, Au R, Cabral HJ, Kowall NW, Seshadri, S, Kubilus C, Drake J, Wolf P. Visual Association Pathology in Preclinical AD. Journal Neuropath Exp Neurol June; 65(6): 621-630.

48. Tobin JE, Cui J, Wilk J, Latourelle J, Laramie J, McKee A, Guttman M, Karamohamed S, DeStefano A, Myers R. Sepiapterin reductase expression is increased in Parkinson’s disease brain tissue Brain Research 2007, 1140, 42-44

49. McKee AC, Carreras I, Hossain L, Ryu H, Klein W, Oddo S, LaFerla F, Jenkins B, Kowall N, Dedeoglu A. Ibuprofen reduces intraneuronal Aß, prevents hyperphosphorylated tau and ameliorates cognitive deficits in young triple transgenic Alzheimer mice, Brain Research, 2008 May 1; 1207: 225-36

50. Harper DG, Stopa EG, Kuo-Leblanc V, McKee A, Asayama K, Volicer L, Kowall N, Saitlin A. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain 2008, Jun; 131(Pt 6): 1609-17

51.Hanlon EB, Perelman LT, Vitkin EI, Greco FA, McKee AC, Kowall NW. Scattering differentiates Alzheimer disease in vitro. Opt Lett 2008, 15:33 (6): 624-26

52. T Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA; MIRAGE Study Group. Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol. 2008 Dec; 65(12): 1640-8

53. Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11): 1501-9

54. McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee H-Y, Kubilus CA, Stern RA. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy following Repetitive Head Injury. J Neuropath Exp Neurol, 2009 68(7): 709-735

55. Yamin R, Zhao C, O’Connor PB, McKee AC, Abraham CR. Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Mol Neurodegener. 2009 Jul 23; 4(1): 33

56. Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer’s disease. PLoS One. 2009 Aug 12; 4(8): e661

57. Van Deerlin V, Sleiman P, Martinez-Lage M, Chen-Plotkin A, Wang L, Graff-Radford N, Dickson D, McKee A, Lee VM. (GWAS study) Common genetic variants at 7p21 show strong association with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Gen, 2010, Mar; 42(3): 234-9

58. Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P; Alzheimer’s Disease Genetics Consortium, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010 Dec; 67(12): 1473-84

59. McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, Perl D, Hedley-Whyte E, Price B, Sullivan C, Morin P, Lee H-S, Kubilus C, Daneshvar D, Wulff M, Budson A. TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy, Journal Neuropathol Exp Neurol, 2010, 69: 918-929

Authors’ reply: McKee AC, Budson AE, Gavett BE, Stern RA, Daneshvar D, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET. J Neuropathol Exp Neurol. 2011 Jan; 70(1): 98-100

60. Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP- 43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010 Oct 11; 5(10): e13250

61. Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H. Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice. Acta Neuropathol. 2011 Apr;121(4):487-98

62. Sullivan CP, Berg EA, Elliott-Bryant R, Fishman JB, McKee AC, Morin PJ, Shia MA, Fine RE. Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer’s disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core. Neurosci Lett. 2011 Nov 14;505(2):109-12

63. Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, Jackson B, McKee AC, Alvarez VE, Lee NC, Hall GF. Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease. J Biol Chem. 2012 Feb 3;287(6):3842-9

64. Goldstein LE, Fisher AM, Tagge CA, Zhang X-L,Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC: Chronic Traumatic Encephalopathy

inBlast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model. Sci Trans. Med. Sci Transl Med. 2012 May 16;4(134):134ra60. PMID: 22593173

65. Response to comment on “chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model”.Goldstein LE, McKee AC. Sci Transl Med. 2012 Oct 24;4(157):157lr5. doi: 10.1126/scitranslmed.3004862 PMID: 23100626

66. Au R#, Seshadri S#, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf P, McKee AC. The Framingham Brain Donation Program: Neuropathology Along the Cognitive Continuum Current Alzheimer Research, 2012, Jul;9(6):673-86

67. Jung MK, Kim KY, Lee NY, Kang YS, Hwang YJ, Kim Y, Sung JJ, McKee A, Kowall N, Lee J, Ryu H. Expression of Taurine Transporter (TauT) is Modulated by Heat Shock Factor 1 (HSF1) in Motor Neurons of ALS. Mol Neurobiol. 2012 Nov 23

68. Whitcomb DC, Larusch J, Krasinskas AM, McKee AC, Devlin B. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Nov 11;44(12):1349-54. doi: 10.1038/ng.2466. Epub 2012 Nov 11 PMID: 23143602

69. Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, St George-Hyslop P, Goldstein LE, Farrer LA. δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS One. 2012;7(9): e43728

70. Augustinack JC, Huber KE, Stevens AA, Roy M, Frosch MP, van der Kouwe AJ, Wald LL, Van Leemput K, McKee AC, Fischl B Predicting the location of human perirhinal cortex, Brodmann’s area 35, from MRI. Neuroimage. 2013 Jan 1;64C:32-42

71. Le M, Kim W, Lee S, McKee A, Hall G. Multiple mechanisms of extracellular tau spreading in a non-transgenic tauopathy model. Am J Neurodegeneration, 2012;1(3):316-33. Epub 2012 Nov 25

72. Holton P, Ryten M, Nalls M, McKee AC, …Younkin SG. Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci. Ann Hum Genet. 2013 Mar;77(2):85-105. doi: 10.1111/ahg.12000. Epub 2013 Jan 30

73. McKee AC,
The Spectrum of Disease in Chronic Traumatic Encephalopathy, Brain 2013,

Jan;136(Pt 1):43-64. doi: 10.1093/brain/aws307

74. Peskind ER, Brody D, Cernak I, McKee A, Ruff RL. Military- and sports-related mild traumatic brain injury: clinical presentation, management, and long-term consequences. J Clin Psychiatry. 2013 Feb;74(2):180-8. doi: 10.4088/JCP.12011co1c

75. Seichepine DR, Stamm JM, Daneshvar DH, Riley DO, Baugh CM, Gavett BE, Tripodis Y, Martin B, Chaisson C, McKee AC, Cantu RC, Nowinski CJ, Stern R. Profile of self-reported problems with executive functioning in college and professional football players. J Neurotrauma. 2013 Feb 19

Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS,

Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin

BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW,

Cantu RC.

76. Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R; Alzheimer Disease Genetics Consortium. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ε4, and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013 Apr 10;309(14):1483-92. doi: 10.1001/jama.2013.2973

77. Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A. 2013 Jul 1. [Epub ahead of print]

78. Weiner MW, Friedl KE, Pacifico A, Chapman JC, Jaffee MS, Little DM, Manley GT, McKee A, Petersen RC, Pitman RK, Yaffe K, Zetterberg H, Obana R, Bain LJ, Carrillo MC. Military risk factors for Alzheimer’s disease. Alzheimers Dement. 2013 Jul;9(4):445-51. doi: 10.1016/j.jalz.2013.03.005

79. Factor-Litvak P, Al-Chalabi A, Ascherio A, Bradley W, Chío A, Garruto R, Hardiman O, Kamel F, Kasarskis E, McKee A, Nakano I, Nelson LM, Eisen A. Current pathways for epidemiological research in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013 May;14 Suppl 1:33-43

80. Brady CB, Trevor KT, Stein TD, Deykin EY, Perkins SD, Averill JG, Guilderson L, McKee AC, Renner SW, Kowall NW. The Department of Veterans Affairs Biorepository Brain Bank: A national resource for amyotrophic lateral sclerosis research. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Aug 23

81. Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC. Clinical presentation of chronic traumatic encephalopathy. Neurology. 2013 Aug 21

82. Pekkala S, Wiener D, Himali JJ, Beiser AS, Obler LK, Liu Y, McKee A, Auerbach S, Seshadri S, Wolf PA, Au R. Lexical retrieval in discourse: An early indicator of Alzheimer’s dementia. Clin Linguist Phon. 2013 Aug 28

83. Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A. 1.R- flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer’s disease. Brain Res. 2013 Dec 6;1541:115-27. PMID: 24161403

84. Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, Frosch MP, Alafuzoff I, Antonell A, Bogdanovic N, Brooks W, Cairns NJ, Cooper-Knock J, Cotman C, Cras P, Cruts M, De Deyn PP, Decarli C, Dobson-Stone C, Engelborghs S, Fox N, Galasko D, Gearing M, Gijselinck I, Grafman J, Hartikainen P, Hatanpaa KJ, Highley JR, Hodges J, Hulette C, Ince PG, Jin LW, Kirby J, Kofler J, Kril J, Kwok JB, Levey A, Lieberman A, Llado A, Martin JJ, Masliah E, McDermott CJ, McKee A, McLean C, Mead S, Miller CA, Miller J, Munoz DG, Murrell J, Paulson H, Piguet O, Rossor M, Sanchez-Valle R, Sano M, Schneider J, Silbert LC, Spina S, van der Zee J, Van Langenhove T, Warren J, Wharton SB,

White Iii CL, Woltjer RL, Trojanowski JQ, Lee VM, Van Deerlin V, Chen-Plotkin AS. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Acta Neuropathol. 2014 Jan 19. PMID: 24442578

85. Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, Frosch MP, Alafuzoff I, Antonell A, Bogdanovic N, Brooks W, Cairns NJ, Cooper-Knock J, Cotman C, Cras P, Cruts M, De Deyn PP, DeCarli C, Dobson-Stone C, Engelborghs S, Fox N, Galasko D, Gearing M, Gijselinck I, Grafman J, Hartikainen P, Hatanpaa KJ, Highley JR, Hodges J, Hulette C, Ince PG, Jin LW, Kirby J, Kofler J, Kril J, Kwok JB, Levey A, Lieberman A, Llado A, Martin JJ, Masliah E, McDermott CJ, McKee A, McLean C, Mead S, Miller CA, Miller J, Munoz DG, Murrell J, Paulson H, Piguet O, Rossor M, Sanchez-Valle R, Sano M, Schneider J, Silbert LC, Spina S, van der Zee J, Van Langenhove T, Warren J, Wharton SB, White CL 3rd, Woltjer RL, Trojanowski JQ, Lee VM, Van Deerlin V, Chen-Plotkin AS.TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Acta Neuropathol. 2014 Mar;127(3):407-18. doi: 10.1007/s00401-013-1239-x. Epub 2014 Jan 19

86. Kaur B, Himali JJ, Seshadri S, Beiser AS, Au R, McKee AC, Auerbach S, Wolf PA, Decarli CS. Association Between Neuropathology and Brain Volume in The Framingham Heart Study. Alzheimer Dis Assoc Disord. 2014 Mar 7

85. Robbins CA, Daneshvar DH, Picano JD, Gavett BE, Baugh CM, Riley DO, Nowinski CJ, McKee AC, Cantu RC, Stern RA. Self-reported concussion history: impact of providing a definition of concussion Open Access J Sports Med. 2014 May 7;5:99-103. doi: 10.2147/OAJSM.S58005

87. Saman S, Lee NC, Inoyo I, Jin J, Li Z, Doyle T, McKee AC, Hall GF. Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer’s disease. J Alzheimers Dis. 2014 Jan 1;40(0): S47-70. doi: 10.3233/JAD-132135.

88. Baugh CM, Kiernan PT, Kroshus E, Daneshvar DH, Montenigro PH, McKee AC, Stern R. Frequency of head impact related outcomes by position in NCAA Division I collegiate football players. J Neurotrauma. 2014 Aug 26

89. Smith AM, Stuart MJ, Dodick DW, Roberts WO, Alford PW, Ashare AB, Aubrey M, Benson BW, Burke CJ, Dick R, Eickhoff C, Emery CA, Flashman LA, Gaz DV, Giza CC, Greenwald RM, Herring SA, Hoshizaki TB, Hudziak JJ, Huston J 3rd, Krause D, LaVoi N, Leaf M, Leddy JJ, MacPherson A, McKee AC, Mihalik JP, Moessner AM, Montelpare WJ, Putukian M, Schneider KJ, Szalkowski R, Tabrum M, Whitehead JR, Wiese-Bjornstal DM. Ice Hockey Summit II: Zero Tolerance for Head Hits and Fighting. PMR. 2015 Mar;7(3):283-95. doi: 10.1016/j.pmrj.2015.02.002. PMID: 25797614

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103. Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of early pathological tau conformations and phosphorylation in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. 2015 Dec 15. pii: nlv001 PMID: 26671985

104. McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Stewart W, Vonsattel JP, Tripodis Y, Alvarez VE, Bieniek KF, Crary J, Dams-O’Connor K, Gordon W and the TBI/CTE group. The First NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. Acta Neuropathol. 2016 Jan;131(1):75-86. doi: 10.1007/s00401-015-1515-z.

105. Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ. A quantitative study of tau pathology in eleven cases of chronic traumatic encephalopathy.Neuropathol Appl Neurobiol. 2016 Mar 21

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110. Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer’s Disease Pathology.J Alzheimers Dis. 2016 Jul 6. PMID: 27392855

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112. Woerman AL, Aoyagi A, Patel S, Kazmi S, Lobach I, Grinberg L, McKee A, Seeley W, Olson S, and Prusiner S. Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50): E8187-E8196

113. Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Inj. 2016; 30 (12):1399-1413

114. Cherry JD, Tripodis Y, Alvarez VE, Huber B, Kiernan PT, Daneshvar DH, Mez J, Montenigro PH, Solomon TM, Alosco ML, Stern RA, McKee AC, Stein TD. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016 Oct 28;4(1):112

115. Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton- Nelson KL, Inzelberg R, Kamboh MI, Kauwe JS, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR; Alzheimer’s Disease Genetics Consortium, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer’s disease loci. Alzheimers Dement. 2017 Feb 7. pii: S1552- 5260(17)30003-1. doi: 10.1016/j.jalz.2016.12.012

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117. Alosco ML, Duskin J, Besser LM, Martin B, Chaisson CE, Gunstad J, Kowall NW, McKee AC, Stern RA, Tripodis Y. Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer’s Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer’s Coordinating Center Data Set. J Alzheimers Dis. 2017;57(3):953-968. doi: 10.3233/JAD-161205

118. Gangolli M, Holleran L, Hee Kim J, Stein TD, Alvarez V, McKee AC, Brody DL. Quantitative validation of a nonlinear histology-MRI co-registration method using generalized Q-sampling imaging in complex human cortical white matter. Neuroimage. 2017 Jun; 153:152- 167. doi: 10.1016/j.neuroimage.2017.03.059. Epub 2017 Mar 30. PMID: 28365421

119. Saygin ZM, Kliemann D, Iglesias JE, van der Kouwe AJW, Boyd E, Reuter M, Stevens A, Van Leemput K, McKee A, Frosch MP, Fischl B, Augustinack JC; Alzheimer’s Disease Neuroimaging Initiative. High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas. Neuroimage. 2017 May 4. pii: S1053- 8119(17)30342-7. doi: 10.1016/j.neuroimage.2017.04.046. PMID:28479476: PMCID: PMC5557007

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167. Alosco ML, Cherry JD, Huber BR, Tripodis Y, Baucom Z, Kowall NW, Saltiel N, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Palmisano JN, Martin B, Cantu RC, Stern RA, Alvarez VE, Mez J, Stein TD, McKee AC. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme. Acta Neuropathol. 2020 Oct;140(4):495-512. doi: 10.1007/s00401-020-02197-9. Epub 2020 Aug 11. PMC7914059 PMID: 32778942: PMCID: PMC7914059

168. Zlokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, González HM, Schneider J, Wellington CL, Katusic ZS, Stoeckel L, Anderson D, Koenig JI, Corriveau RA, Fine L, Galis ZS, Reis J, Wright JD, Chen J. Vascular contributions to cognitive impairment and

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169. Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C; Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2020 Oct 19:e203536. doi: 10.1001/jamaneurol.2020.3536. Online ahead of print. PMID: 33074286: PMCID: PMC7573798

170. Pelcher I, Puzo C, Tripodis Y, Aparicio HJ, Steinberg EG, Phelps A, Martin B, Palmisano JN, Vassey E, Lindbergh C, McKee AC, Stein TD, Killiany RJ, Au R, Kowall NW, Stern RA,

National Institute of Neurological Disorders and Stroke Workshop.

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171. Mez J, Daneshvar DH, Alosco ML, Alvarez VE, Huber BR, Stein TD, McKee AC. Reply to “Chronic Traumatic Encephalopathy and Primary Age-Related Tauopathy”.
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172. Spencer KR, Foster ZW, Rauf NA, Guilderson L, Collins D, Averill JG, Walker SE, Robey I, Cherry JD, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB, Stein TD. Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans. Brain Pathol. 2020 Nov;30(6):1028-1040. doi: 10.1111/bpa.12876. Epub 2020 Aug 4. PMID: 32633852: PMCID: PMC8018169

173. Cherry JD, Meng G, Daley S, Xia W, Svirsky S, Alvarez VE, Nicks R, Pothast M, Kelley H, Huber B, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy.
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174. Girgenti MJ, Wang J, Ji D, Cruz DA; Traumatic Stress Brain Research Group, Stein MB, Gelernter J, Young KA, Huber BR, Williamson DE, Friedman MJ, Krystal JH, Zhao H, Duman RS. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nat Neurosci. 2020 Dec 21. doi: 10.1038/s41593-020-00748-7. Online ahead of print.

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175. Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunuan V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2020 Dec 23:nlaa153. doi: 10.1093/jnen/nlaa153. Online ahead of print. PMID: 33367843: PMCID: PMC8453611

177. Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O’Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley ÉM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome. Neurology. 2021 Mar 15:10.1212/WNL.0000000000011850. doi: 10.1212/WNL.0000000000011850. Online ahead of print. PMID: 33722990; PMCID: PMC8166432

178. Mez J, Alosco ML, Daneshvar DH, Saltiel N, Baucom Z, Abdolmohammadi B, Uretsky M, Nicks R, Martin BM, Palmisano JN, Nowinski CJ, Montenigro P, Solomon TM, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Goldstein LE, Katz DI, Cantu RC, Kowall NW, Tripodis Y, Huber BR, Stein TD, Stern RA, McKee AC. Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology. Alzheimers Dement. 2021 Apr 7. doi: 10.1002/alz.12338. Online ahead of print. PMID: 33826224: PMCID PMC8596795

179. Cherry JD, Esnault CD, Baucom ZH, Tripodis Y, Huber BR, Alvarez VE, Stein TD, Dickson DW, McKee AC. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease Acta Neuropathol Commun. 2021 May 12;9(1):86. doi: 10.1186/s40478-021-01189-4. PMID: 33980303: PMCID: PMC8114683

180. Chancellor KB, Chancellor SE, Duke-Cohan JE, Huber BR, Stein TD, Alvarez VE, Okaty BW, Dymecki SM, McKee AC. Altered oligodendroglia and astroglia in chronic traumatic encephalopathy. Acta Neuropathol. 2021 May 21. doi: 10.1007/s00401-021-02322-2. Online ahead of print. PMID: 34019156: PMCID: PMC8270845

181. Gutierrez-Quiceno L, Dammer EB, Johnson AG, Webster JA, Shah R, Duong D, Yin L, Seyfried NT, Alvarez VE, Stein TD, McKee AC, Hales CM. A proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy. Mol Neurodegener. 2021 Jun 25;16(1):40. doi: 10.1186/s13024-021-00462-3. PMID: 34172091 PMCID: PMC8235576

182. Greco FA, McKee AC, Kowall NW, Hanlon EB. Near-Infrared Optical Spectroscopy In Vivo Distinguishes Subjects with Alzheimer’s Disease from Age-Matched Controls.
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183. Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, Dickson DW, McKee AC, Stein TD, Trojanowski JQ, Woltjer RL, Kovacs GG, Kofler JK, Kaye J, White CL 3rd, Crary JF. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathol Commun. 2021 Aug 5;9(1):134. doi: 10.1186/s40478-021- 01233-3. PMID: 34353357: PMCID: 8340493

184. Alosco ML, Mariani ML, Adler CH, Balcer LJ, Bernick C, Au R, Banks SJ, Barr WB, Bouix S, Cantu RC, Coleman MJ, Dodick DW, Farrer LA, Geda YE, Katz DI, Koerte IK, Kowall NW, Lin AP, Marcus DS, Marek KL, McClean MD, McKee AC, Mez J, Palmisano JN, Peskind ER, Tripodis Y, Turner RW 2nd, Wethe JV, Cummings JL, Reiman EM, Shenton ME, Stern RA; DIAGNOSE CTE Research Project Investigators. Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project. Alzheimers Res Ther. 2021 Aug 12;13(1):136. doi: 10.1186/s13195-021-00872-x. PMID: 34384490: PMCID: PMC8357968

185. Mez J, Alosco ML, Nowinski CJ, McKee AC, Tripodis Y. Reader Response: Association of Position Played and Career Duration and Chronic Traumatic Encephalopathy at Autopsy in Elite Football and Hockey Players. Neurology. 2021 Aug 10;97(6):297-298. doi: 10.1212/WNL.0000000000012381. PMID: 34373356: PMCID: PMC8589270

186. Alosco ML, Mariani ML, Adler CH, Balcer LJ, Bernick C, Au R, Banks SJ, Barr WB, Bouix S, Cantu RC, Coleman MJ, Dodick DW, Farrer LA, Geda YE, Katz DI, Koerte IK, Kowall NW, Lin AP, Marcus DS, Marek KL, McClean MD, McKee AC, Mez J, Palmisano JN, Peskind ER, Tripodis Y, Turner RW 2nd, Wethe JV, Cummings JL, Reiman EM, Shenton ME, Stern RA; DIAGNOSE CTE Research Project Investigators. Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project. Alzheimers Res Ther. 2021 Aug 12;13(1):136. doi: 10.1186/s13195-021-00872-x. PMID: 34384490: PMCID: PMC8357968

187. Cherry JD, Agus F, Dixon E, Huber B, Alvarez VE, Mez J, McKee AC, Labadorf A, Stein TD. Differential gene expression in the cortical sulcus compared to the gyral crest within the early stages of chronic traumatic encephalopathy. Free Neuropathol. 2021;2:3453. doi: 10.17879/freeneuropathology-2021-3453. Epub 2021 Aug 17. PMID: 34485990: PMCID: PMC8415801

188. Kaufman SK, Svirsky S, Cherry JD, McKee AC, Diamond MI. Tau seeding in chronic traumatic encephalopathy parallels disease severity. Acta Neuropathol. 2021 Oct 9. doi: 10.1007/s00401-021-02373-5. Online ahead of print. PMID: 34626223: PMCID: PMC87632021

189. Brady CB, Robey I, Stein TD, Huber BR, Riley J, Abdul Rauf N, Spencer KR, Walt G, Adams L, Averill JG, Walker S, McKee AC, Thomson SP, Kowall NW. The Department of Veterans Affairs Gulf War Veterans’ Illnesses Biorepository: Supporting Research on Gulf War Veterans’ Illnesses. Brain Sci. 2021 Oct 14;11(10):1349. doi: 10.3390/brainsci11101349.

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190. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2021 Nov 1. doi: 10.1007/s00401-021- 02379-z. Online ahead of print. PMID: 34719765: PMCID: PMC878660

191. Uretsky M, Bouix S, Killiany RJ, Tripodis Y, Martin B, Palmisano J, Mian AZ, Buch K, Farris C, Daneshvar DH, Dwyer B, Goldstein L, Katz D, Nowinski C, Cantu R, Kowall N, Huber BR, Stern RA, Alvarez VE, Stein TD, McKee A, Mez J, Alosco ML. Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts. 2021 Nov Neurology. 2022 Jan 4;98(1):e27-e39. doi: 10.1212/WNL.0000000000013012. Epub 2021 Nov 24. PMID: 34819338: PMCID:PMC8726571

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193. Alosco ML, Mian AZ, Buch K, Farris CW, Uretsky M, Tripodis Y, Baucom Z, Martin B, Palmisano J, Puzo C, Ang TFA, Joshi P, Goldstein LE, Au R, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Huber BR, Alvarez VE, Stern RA, Stein TD, Killiany RJ, McKee AC, Mez J. Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE. Alzheimers Res Ther. 2021 Dec 7;13(1):193. doi: 10.1186/s13195-021-00928-y. PMID: 34876229: PMCID: PMC8653514

194. Daneshvar DH, Mez J, Alosco ML, Baucom ZH, Mahar I, Baugh CM, Valle JP, Weuve J, Paganoni S, Cantu RC, Zafonte RD, Stern RA, Stein TD, Tripodis Y, Nowinski CJ, McKee AC. Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes. JAMA Netw Open. 2021 Dec 1;4(12):e2138801. doi: 10.1001/jamanetworkopen.2021.38801. PMID: 34910152: PMCID: PMC8674746

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196. Glass JD, Hammers JL, Omalu BL, Bieniek KF, Crary JF, Dickson DW, Stein TD, Mez J, Alosco ME, McKee AC. Erratum to Letters to the Editor regarding: The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol 2021;80(3):210-9. J Neuropathol Exp Neurol. 2022 Jan 31:nlac003. doi: 10.1093/jnen/nlac003. Online ahead of print. PMID: 35098301

197. Turk KW, Geada A, Alvarez VE, Xia W, Cherry JD, Nicks R, Meng G, Daley S, Tripodis Y, Huber BR, Budson AE, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Alosco ML, Mez J, McKee AC, Stein TD. A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease. Alzheimers Res Ther. 2022 Feb 9;14(1):28. doi: 10.1186/s13195-022-00976-y. PMID: 35139894: PMCID: PMC8830027

199. Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, et al. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Nat Genet. 2022 Apr 4. doi: 10.1038/s41588-022-01024-z. Online ahead of print. PMID: 35379992: pMCID: PMC9005347

200. Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW, Martin ER, Naj AC, Ertekin-Taner N, Golde TE, Hood L, Price ND; Alzheimer’s Disease Genetics Consortium. Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90.Sci Rep. 2022 Apr 12;12(1):6117. doi: 10.1038/s41598-022-09825-2. PMID: 35413975 PMCID: PMC9005657

201. Babcock KJ, Abdolmohammadi B, Kiernan PT, Mahar I, Cherry JD, Alvarez VE, Goldstein LE, Stein TD, McKee AC, Huber BR. Interface astrogliosis in contact sport head impacts and military blast exposure.Acta Neuropathol Commun. 2022 Apr 13;10(1):52. doi: 10.1186/s40478- 022-01358-z.PMID: 35418116: PMCID:9009003.

202. LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Selection Bias Analysis Supports Dose-Response Relationship between Level of American Football Play and Chronic Traumatic Encephalopathy Diagnosis. Am J Epidemiol. 2022 Apr 16:kwac075. doi: 10.1093/aje/kwac075. Online ahead of print. PMID: 35434739

203. Morrison MS, Aparicio HJ, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Tripodis Y, Martin B, Palmisano JN, Sugarman MA, Frank B, Steinberg EG, Turk KW, Budson AE, Au R, Goldstein LE, Jun GR, Kowall NW, Killiany R, Qiu WQ, Stern RA, Mez J, McKee AC, Stein TD, Alosco ML. Antemortem plasma phosphorylated tau (181) predicts Alzheimer’s disease neuropathology and regional tau at autopsy. 2022 Oct 21;145(10):3546-3557. doi: 10.1093/brain/awac175. PMID: 35554506

204. Yang J, Chang S, Chen IA, Kura S, Rosen GA, Saltiel NA, Huber BR, Varadarajan D, Balbastre Y, Magnain C, Chen SC, Fischl B, McKee AC, Boas D, Wang H. Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical

coherence tomography. IEEE Trans Biomed Eng. 2022 May 13;PP. doi: 10.1109/TBME.2022.3175072. Online ahead of print. PMID: 35560084

205. Colvin LE, Foster ZW, Stein TD, Thakore-James M, Salajegheh MK, Carr K, Spencer KR, Abdul Rauf N, Adams L, Averill JG, Walker SE, Robey I, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB. Utility of the ALSFRS-R for Predicting ALS and Comorbid Disease Neuropathology: The Veterans Affairs Biorepository Brain Bank. Muscle Nerve. 2022 May 18. doi: 10.1002/mus.27635. Online ahead of print. PMID: 35585776: PMCID: PMC9308705

206. Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022 May 19;16:855096. doi: 10.3389/fnins.2022.855096. eCollection 2022.

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207. Frank B, Ally M, Tripodis Y, Puzo C, Labriolo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O’Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 Jun 14;98(24):e2454-e2464. doi: 10.1212/WNL.0000000000200304. Epub 2022 Apr 20. PMID: 35444054: PMCID: PMC 9231841

208. Atherton K, Han X, Chung J, Cherry JD, Baucom Z, Saltiel N, Nair E, Abdolmohammadi B, Uretsky M, Khan MM, Shea C, Durape S, Martin BM, Palmisano JN, Farrell K, Nowinski CJ, Alvarez VE, Dwyer B, Daneshvar DH, Katz DI, Goldstein LE, Cantu RC, Kowall NW, Alosco ML, Huber BR, Tripodis Y, Crary JF, Farrer L, Stern RA, Stein TD, McKee AC, Mez J. Association of APOE Genotypes and Chronic Traumatic Encephalopathy. JAMA Neurol. 2022 Jun 27. doi: 10.1001/jamaneurol.2022.1634. Online ahead of print. PMID: 35759276: PMCID: PMC 9237800

209. Butler MLMD, Dixon E, Stein TD, Alvarez VE, Huber B, Buckland ME, McKee AC, Cherry JD. Tau Pathology in Chronic Traumatic Encephalopathy is Primarily Neuronal. J Neuropathol Exp Neurol. 2022 Jul 28:nlac065. doi: 10.1093/jnen/nlac065. Online ahead of print. PMID: 35903039: PMCID: PMC 9487650

210. Lee J, Kim S, Kim YH, Park U, Lee J, McKee AC, Kim KH, Ryu H, Lee J. Non-Targeted Metabolomics Approach Revealed Significant Changes in Metabolic Pathways in Patients with Chronic Traumatic Encephalopathy. Biomedicines. 2022 Jul 15;10(7):1718. doi: 10.3390/biomedicines10071718. PMID: 35885023: PMCID: PMC 9313062

211. Moncaster JA, Moir RD, Burton MA, Chadwick O, Minaeva O, Alvarez VE, Ericsson M, Clark JI, McKee AC, Tanzi RE, Goldstein LE. Alzheimer’s disease amyloid-β pathology in the lens of the eye. Exp Eye Res. 2022 Aug;221:108974. doi: 10.1016/j.exer.2022.108974. Epub 2022 Feb 21.PMID: 35202705: PMCID: PMC9873124

212. LeClair J, Weuve J, Fox MP, Mez J, Alosco ML, Nowinski C, McKee A, Tripodis Y. Relationship Between Level of American Football Playing and Diagnosis of Chronic Traumatic

Encephalopathy in a Selection Bias Analysis. Am J Epidemiol. 2022 Jul 23;191(8):1429-1443. doi: 10.1093/aje/kwac075.PMID: 35434739: PMCID: PMC9989358

213. Colvin LE, Foster ZW, Stein TD, Thakore-James M, Salajegheh MK, Carr K, Spencer KR, Abdul Rauf N, Adams L, Averill JG, Walker SE, Robey I, Alvarez VE, Huber BR, McKee AC, Kowall NW, Brady CB. Utility of the ALSFRS-R for predicting ALS and comorbid disease neuropathology: The Veterans Affairs Biorepository Brain Bank. Muscle Nerve. 2022 Aug;66(2):167-174. doi: 10.1002/mus.27635. Epub 2022 Jun 4. PMID: 35585776: PMCID: PMC 9308705

214. Roemer SF, Grinberg LT, Crary JF, Seeley WW, McKee AC, Kovacs GG, Beach TG, Duyckaerts C, Ferrer IA, Gelpi E, Lee EB, Revesz T, White CL 3rd, Yoshida M, Pereira FL, Whitney K, Ghayal NB, Dickson DW. Rainwater Charitable Foundation criteria for the neuropathologic diagnosis progressive supranuclear palsy. Acta Neuropathol. 2022 Aug 10. doi: 10.1007/s00401-022-02479-4. Online ahead of print. PMID: 35947184: PMCID: PMC 9468104

215. Stathas S, Alvarez VE, Xia W, Nicks R, Meng G, Daley S, Pothast M, Shah A, Kelley H, Esnault C, McCormack R, Dixon E, Fishbein L, Cherry JD, Huber BR, Tripodis Y, Alosco ML, Mez J, McKee AC, Stein TD. Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer’s disease. Alzheimers Dement. 2022 Aug;18(8):1511-1522. doi: 10.1002/alz.12502. Epub 2021 Dec 2. PMID: 34854540: PMCID: PMC 9160206

216. Alosco ML, Tripodis Y, Baucom ZH, Adler CH, Balcer LJ, Bernick C, Mariani ML, Au R, Banks SJ, Barr WB, Wethe JV, Cantu RC, Coleman MJ, Dodick DW, McClean MD, McKee AC, Mez J, Palmisano JN, Martin B, Hartlage K, Lin AP, Koerte IK, Cummings JL, Reiman EM, Stern RA, Shenton ME, Bouix S; DIAGNOSE CTE Research Project. White matter hyperintensities in former American football players. Alzheimers Dement. 2023 Apr;19(4):1260- 1273 epub 2022 Aug 22. doi: 10.1002/alz.12779. PMID: 35996231; PMCID: PMC10351916

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