Population Responses of Living Neural Networks to Periodic Drive
Project Description
The hippocampal formation (HF) in mammals is responsible for collecting information about the sensory world and, if appropriate, storing that information as memories, to be offloaded to other brain structures later. The HF has a number of notable response properties, including nested, quasi-periodic activity. In this project, the student will work with us to collect and analyze data related to responses to periodic drive, collected via novel microscopy and voltage-imaging methods.
Mentors
| John White, PI | Brandon Williams |
|
|
|
Research Goals
The student will work with Mr. Williams on all aspects of the project, including:
• Biological preparations for in vitro recordings
• Novel confocal microscopy methods
• Introduction of genetically encoded agents for imaging membrane potential in neurons with cellular resolution
• Analysis of imaging data
5. Post-hoc imaging analysis to identify specific neuronal cell types in the preparation.
• Biological preparations for in vitro recordings
• Novel confocal microscopy methods
• Introduction of genetically encoded agents for imaging membrane potential in neurons with cellular resolution
• Analysis of imaging data
5. Post-hoc imaging analysis to identify specific neuronal cell types in the preparation.
Learning Goals
• Lab safety
• Humane use of experimental animals
• Applied molecular biology
• Advanced microscopy
• Signal processing methods
6. Image registration
• Humane use of experimental animals
• Applied molecular biology
• Advanced microscopy
• Signal processing methods
6. Image registration