Graduate Prerequisites: *Can^t be taken together for credit with SPH EH 705 - The Global Burden of Disease analysis shows that environmental factors contribute substantially to morbidity and mortality worldwide. This course is designed both to introduce fundamental concepts in toxicology and to delve more deeply into the critical elements that are necessary to explain the responses of populations to environmental hazards, with an emphasis on chemicals. This course will provide students with the tools to identify toxicological data that support the biological plausibility of a chemical exposure leading to an adverse health outcome, which is critical to strengthening associations identified by epidemiological analyses. This in-depth introduction includes toxicokinetics and toxicodynamics. Particulate matter, arsenic and perfluoroalkyl substance exposures, along with others, will be used as examples to demonstrate how toxicity and carcinogenesis can be induced in representative organs systems, including the respiratory, endocrine/reproductive, immune, and nervous systems.

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