The Future Talent Program features Cooperative (Co-op) education that lasts up to 6 months and will include one or more projects.  These opportunities in our Research Labs can provide you with great development and a chance to see if we are the right company for your long-term goals.

Our Research & Development Division’s Adsorption, Distribution and Metabolite Identification group with in Pharmacodynamics, Pharmacokinetics and Drug Metabolism Department in Boston, MA is seeking a highly motivated co-op graduate student to conduct research in drug metabolism of small molecules with emphasis in glucuronidation and glucuronosyltransferase reaction phenotyping.   Some responsibilities will include:

• Quantitative reaction phenotyping:  ISEF’s for rhUGT enzymes and liver/intestinal microsomes
• Literature review and deployment of acceptable isoform selective probes and inhibitors including pressure-tests.
• Explore the use of UGT antibodies or siRNAs.
• Optimization of UGT kinetics assay including low turnover compounds and UGT inhibition assays.
• Enzyme kinetics work to qualify selective probe substrates based on EMA feedback.

We are seeking co-op candidates with a strong academic performance, communication skills, teamwork, and the ability to work in a multi- functional environment.

Required Education and Experience:

• Candidates must be available to work full-time for up to 6 months beginning in January or June of 2020.
• Candidates must be a second to fourth year graduate student pursuing a degree in biology, biochemistry, chemistry or related fields with particular emphasis in enzyme kinetics.
• Candidates must have experience with in vitro enzyme incubation and LC-MS/MS is highly desirable.

Preferred Experience and Skills:

• Candidates should have Invitro enzyme experience
• Candidates should have drug metabolism of small molecules experience
• Candidates should have Enzyme kinetics experience
• Candidates should have LC-MS/MS
• Candidates should have a GPA of 3.0 or higher.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.