Research Tools and Applications
Below you will find several categories of computational research tools, databases and applications developed by members of the BU Bioinformatics community.
Carrie Generate transcriptional regulatory networks from microarray and promoter sequence data
CisML An XML format for Sequence Motif Detection Programs
Cis‐element info Count matrices and background info for some /cis/‐elements
ICSF Identifies conserved structural features at sequentially degenerate locations in transcription factor binding sites
Possum Simple matrix‐based motif search
Promoser Human mouse and rat promoter extraction service
REPFIND Find clustered, exact repeats in nucleotide sequences
Site2genome Locate sites in the human, mouse and rat genomes
Cluster‐Buster Program for finding clusters of pre‐specified motifs in nucleotide sequences
Comet Cluster of Motifs E‐value Tool finds statistically significant clusters of motifs in a DNA sequence
Cister Cister predicts regulatory regions in DNA sequences by searching for clusters of cis‐elements.
Clover Find overrepresented motifs in DNA sequences
CompAlign Employs the mechanisms of string matching and string comparison yet avoids the overdependence of those methods on position‐by‐position matching
FastER Identification of genes with fast‐evolving regions in closely related genomes
GEMS Gene Expression Module Sampler biclustering based on a Gibbs sampling paradigm
GLAM Gapless Local Alignment of Multiple sequences: program for discovering functional motifs shared by a set of nucleotide sequences
MotifViz Integration of tools for detecting overrepresented motifs
RANKGENE Program for analyzing gene expression data, feature selection and ranking genes based on the predictive power of each gene to classify samples into functional or disease categories
ROVER Find relatively overrepresented motifs in DNA sequences
SeqVISTA A viewer of sequences and their annotations; now with a Motif module for integrating transcriptional regulation analysis tools
Tractor Program to computationally identify transcription factors with over‐represented binding sites in the upstream regions of co‐expressed human genes
K2 A genetic algorithm‐based protein structure alignment tool
FAST A newer protein structure alignment tool, based on graph theory
SMM A matrix‐based algorithm for predicting peptides binding to Major Histocompatibility Complex
ZDOCK Rigid‐body protein‐protein docking software, using a Fast Fourier Transform search algorithm
RDOCK A refinement method to minimize energy and re‐rank ZDOCK predictions
Docking Benchmark A large set of test cases for evaluating the performance of docking algorithms
ZDOCK Conv3D ZDOCK optimized with a new convolution library, resulting in improved speed and less memory usage
ZDOCK Server An automated server for running ZDOCK, with capabilities for blocking and filtering contact residues
GeneChords Retrieve conserved gene cluster data from a number of microbial genomes as well as perform searches based on genomic context
GENEVA Catalogues SVGs (segmentally variable genes) in several complete microbial genomes.
HuGE Index Database of gene expression in normal human tissues
Inverted Repeats Finder Public repository of information on inverted repeats in genomic DNA
ORChID The ∙OH Radical Cleavage Intensity Database (∙ORChID) stores hydroxyl radical cleavage data of DNA sequences
Operons Functional Gene Clusters, Operons with applications to bacterial microarray analys, pathway reconstruction, functional annotation, and system biology based on graph matching
Optimus Retrieve conserved gene cluster data from a number of microbial genomes as well as perform searches based on genomic context
Predictome Tool for visualizing the predicted functional associations among genes and proteins in many different organisms
Tandem Repeat Database Public repository of information on tandem repeats in genomic DNA
VisANT Web‐based software framework for visualizing and analyzing many types of networks of biological interactions and associations
ELISA Evolutionary Lineage Inferred from Structural Alignment
BSG Graphical Theoretical Prediction of Transcription Factor Binding Sites
SVMotif A SVM Based Transcription Factor Binding Motif Finder
TFSVM Transcription Factor Binding Site Detection by Machine Learning
OHMICS Oral Human Microbiome Integrated Computational System