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Dr. Angela Ho and Christina Gallo (PhD in Pharmacology student and member of the Ho/Beffert lab) recently received grants from the National Institute on Aging the National Institutes of Health. Dr. Ho received a R21 grant from NIA/NIH. The project’s goal is to determine the specificity of the cell-permeable APP mimetic peptide to disrupt the APP-Mint interaction and reduce Ab accumulation in Alzheimer’s disease mouse models. This work is based on a recent publication from a collaboration with Dr. Kristian Stromgaard’s laboratory at University of Copenhagen where co-first author, Shawna Henry (PhD in Biology, Cell & Molecular student and member of the Ho/Beffert lab) showed that targeting the APP-Mint2 interaction with a peptide-based inhibitor reduces amyloid formation in neuronal in vitro model of Alzheimer’s disease (Bartling CRO, Jensen TMT, Henry SM et al., 2021, Journal of the American Chemical Society).
Christina Gallo received a F31 NRSA award from NIA/NIH to study whether alternative splicing of apoE receptor, apoER2 is altered in the aging and Alzheimer’s disease brains and to uncover modifiers of apoER2 splicing events. Congratulations to Christina and Angela!