Melissa Inge

Current Research:

In chronic infections and cancer, T cells can become “exhausted” and no longer function effectively in clearing viruses, bacteria, or killing cancer cells. My research focuses on examining how key regulators of the epigenome contribute to this exhausted T cell state. In particular, I use various system-level methods to examine the role of histone modifying cofactors and how their interactions with transcription factors lead to this dysfunctional state.