Publications

2024

Danielle Manolakos, Genevieve Patrick, John K. Geisse, Harold Rabinovitz, Kendall Buchanan, Preston Hoang, Eladio Rodriguez-Diaz, Irving J. Bigio, Armand B. Cognetta, Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: A comparative effectiveness study, JAAD International, Volume 14, 52-58 (2024).

2023

Blanke N, Chang S, Novoseltseva A, Wang H, Boas DA, Bigio IJ. Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy. Biomed Opt Express. 2023 Oct 24;14(11):5946-5964.

2022

Eladio Rodriguez-Diaz, Lisa I. Jepeal, György Baffy, Wai-Kit Lo, Hiroshi Mashimo MD, Ousama A’amar, Irving J. Bigio, Satish K. Singh, Artifical Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy, Digestive Diseases and Sciences, 2022 67(2):613-621 (2022)

2021

Nathan Blanke, Veronica Go, Douglas L. Rosene, and Irving J. Bigio“Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey”, Neurophotonics, Vol 8(1) 015010-1:15 (2021).
Eladio Rodriguez-Diaz, Samer Kaanan, Christopher Vanley, Tauseef Quereshi, and Irving J. Bigio, Toward optical spectroscopy-guided lung biopsy: Demonstration of tissue-type classification”, Journal of Biophotonics, 14(10) e202100132 (2021).
Syeda Tabassum, Anup Tank, Fay Wang, Kavon Karrobi, Cameron Vergato, Irving J. Bigio, David J. Waxman, and Darren Roblyer, “Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer”, Neoplasia, 23(3):294-303. (2021)

2019

Mostafa E. Belghasem, Ousama A’amar, Daniel Roth, Joshua Walker, Nkiruka Arinze, Sean M. Richards, Jean M. Francis, David J. Salant, Vipul C. Chitalia, and Irving J. Bigio, “Towards minimally-invasive, quantitative assessment of chronic kidney diseas using optical spectroscopy”, Nature Scientific Reports, 9:7168 (2019)
Eladio Rodriguez-Diaz, Danielle Manolakos, Holly Christman, Michael A. Bonning, John K. Geisse, Ousama M. A’amar, David J. Leffell, and Irving J. Bigio, “Optical Spectroscopy as a Method for Skin Cancer Risk Assessment”, Photochemistry and Photobiology, 2019, 95: 1441-1445.
Uraib Sharaha, Eladio Rodriguez-Diaz, Orli Sagi, Klaris Reisenberg, Ahmad Salman, Irving J. Bigio, and Mahmoud Huleihel, “Fast and reliable determination of Escherichia coli susceptibility to antibiotics: Infrared microscopy in tandem with machine learning algorithms”, J. Biophotonics. 2019 12(7):e201800478.

2018

Ying Zhu, Tom Fearn, D. Wayne Chicken, Martin R. Austwick, Santosh K. Somasundaram, Charles A. Mosse, Benjamin Clark, Irving J. Bigio, Mohammed R.S. Keshtgar, and Stephen G. Bown, “Elastic scattering spectroscopy for early detection of breast cancer: partially supervised Baysean image classification of scanned sentinal lymph nodes”, J. Biomedical Optics 23(8), 085004 (2018).

2017

Gregory A. Grillone, MD, FACS, Zimmern Wang, MD, Gintas P. Krisciunas, MPH, MA, Angela C. Tsai, MD, Vishnu R. Kannabiran, MD, Robert W. Pistey, MD, Qing Zhao, MD, PhD; Eladio Rodriguez-Diaz, PhD, Ousama M. A’Amar, PhD, Irving J. Bigio, PhD,“The Color of Cancer: Margin Guidance for Oral Cancer Resection Using Elastic Scattering Spectroscopy”, Laryngoscope, 127: S1-S9, 2017.
Juliane Nguyen, Shaolie S. Hossain, Johann R.N. Cooke, Jason A. Ellis, Michael B. Deci, Charles W. Emala, Jeffrey N. Bruce, Irving J. Bigio, Robert M Straubinger, Shaliendra Joshi, “Flow arrect intra-areterial delivery of small TAT-decorated and neutral micelles to gliomas”, J Neurooncol. (2017) 133(1):77-85.
Ahmad Salman, Uraib Sharaha, Eladio Rodriguez-Diaz, Elad Shufan, Klaris Riesenberg, Irving J. Bigio, and Mahmoud Huleihel, Detection of antibiotic resistant Escherichia Coli bacteria using infrared microscopy and advanced multivariate analysis, Analyst, 2017, 142, 2136-2144.
Uraib Sharaha, Eladio Rodriguez-Diaz, Klaris Riesenberg, Irving J. Bigio, Mahmoud Huleihel, and Ahmad Salman, “Using Infrared Spectroscopy and Multivariate Analysis to Detect Antibiotics’ Resistant Escherichia coli Bacteria”, Analytical Chemistry, 2017, 89, 8782-8790.

2016

Joseph Angelo, Christina R. Vargas, Bernard T. Lee, Irving J. Bigio, Sylvain Gioux, “Ultrafast optical property map generation using lookup tables,” Opt. 21(11), 110501 (2016),
Badreddine, Ali H., Jordan, T., and Bigio, I. J., “Real-time imaging of action potentials in nerves using changes in birefringence,” , Biomed. Opt. Express 7, 1966–1973 (2016).
Jason A. Ellis, Johann Cooke, Rajinder P. Singh-Moon, Mei Wang, Mei Wang, Jeffrey N. Bruce, Charles W. Emala, Irving J. Bigio, and Shaliendra Joshi, “Safety, feasibility, and optimization of intra-arterial mitoxantrone delivery to gliomas”, J Neurooncol (2016) 130(3):449-454.
Juliane Nguyen, Johann R.N. Cooke, Jason A. Ellis, Michael Deci, Charles W. Emala, Jeffrey N. Bruce, Irving J. Bigio, Robert M. Straubinger, Shaliendra Joshi, “Cationizable lipid micelles as vehicles for intraarterial glioma treatment”, J Neurooncol. (2016) 128:21-28.

2015

Badreddine, Ali H., Schoener, K. J., and Bigio, I. J., “Elucidating the temporal dynamics of optical birefringence changes in crustacean nerves.,” Biomed. Opt. Express 6, 4165–78 (2015).

2014

Singh-Moon, Rajinder P., Roblyer, Darren M., Bigio, Irving J., Joshi, Shailendra, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” Journla of Biomedical Optics 19(9), 096003 (September 2014).
Calabro, Katherine W.,
Bigio, Irving J., “Influence of the phase function in generalized diffuse reflectance models: review of current formalisms and novel observations,” Journal of Biomedical Optics 19(7), 075005 (July 2014).

2013

A’Amar, O. M., Liou, L., Rodriguez-Diaz, E., De las Morenas, A, Bigio, I. J. , “Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for opticallyguided biopsy and directed treatment,” Lasers Med Sci (2013) 28:1323–1329.
J. Rosen, H. Suh, N. Giordano, O. A’amar, E. Rodriguez-Diaz, I. Bigio, and S. Lee , “Preoperative Discrimination of Benign from Malignant Disease in Thyroid Nodules with Indeterminate Cytology Using Elastic Light-Scattering Spectroscopy,” IEEE transactions on bio-medical engineering, Jun. 2013.

2012

Ergin, A., Wang, M., Zhang, J., Bigio, I.J., & Joshi, S., “Noninvasive in vivo optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits,” Journal of Biomedical Optics 17(5), May 2012.

2011

Austwick, M.R., Woodhams, J.H., Chalau, V., Mosse, C. a, Eliot, C., Lovat, L., Macrobert, A.J., Bigio, I.J. & Bown, S.G., “Optical Measurement of Photosensitizer Concentration in Vivo,” Journal of Innovative Optical Health Sciences, vol. 04, 2011, p. 97.
Mulvey, C.S., Zhang, K., Bobby Liu, W.-H., Waxman, D.J. & Bigio, I.J., “Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, Part 2: early spectral changes during apoptosis are linked to apoptotic volume decrease.,” Journal of biomedical optics, vol. 16, Nov. 2011, p. 117002.
Mulvey, C.S., Zhang, K., Liu, W.-H.B., Waxman, D.J. & Bigio, I.J., “Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, Part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures.,” Journal of biomedical optics, vol. 16, Nov. 2011, p. 117001.
Rodriguez-Diaz, E., Castanon, D. a, Singh, S.K. & Bigio, I.J., “Spectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia.,” Journal of biomedical optics, vol. 16, Jun. 2011, p. 067009.
Suh, H., A’amar, O., Rodriguez-Diaz, E., Lee, S., Bigio, I. & Rosen, J.E., “Elastic light-scattering spectroscopy for discrimination of benign from malignant disease in thyroid nodules.,” Annals of surgical oncology, vol. 18, May. 2011, pp. 1300-5.
Rodriguez-Diaz, E., Bigio, I.J. & Singh, S.K., “Integrated Optical Tools for Minimally Invasive Diagnosis and Treatment At Gastrointestinal Endoscopy.,” Robotics and computer-integrated manufacturing, vol. 27, Apr. 2011, pp. 249-256.
A. Ergin, M. Wang, J.Y. Zhang, J.N. Bruce, R. L. Fine, I. J. Bigio, S. Joshi, “The feasibility of real-time in vivo optical detection of blood-brain barrier disruption with indocyanine green,” Journal of Neuro-Oncology (2011)
S. Joshi, R. Reif, M. Wang, J. Zhang, A. Ergin, J. N. Bruce, R. L. Fine, I. J. Bigio, “Intra-arterial Mitoxantrone Delivery in Rabbits: An Optical Pharmocokinetic Study,” Neurosurgery 69: 706-712 (2011)
K. Calabro, A. Curtis, J.-R. Galarneau, T. Krucker, I. J. Bigio, “Gender Variation in the optical properties of skin in murine animal models,” Journal of Biomedical Optics 16 (1), 011008 (2011)

2010

Keshtgar, M.R.S., Chicken, D.W., Austwick, M.R., Somasundaram, S.K., Mosse, C. a, Zhu, Y., Bigio, I.J. & Bown, S.G., “Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer.,” The British journal of surgery, vol. 97, Aug. 2010, pp. 1232-9.
Austwick, M.R., Clark, B., Mosse, C. a, Johnson, K., Chicken, D.W., Somasundaram, S.K., Calabro, K.W., Zhu, Y., Falzon, M., Kocjan, G., Fearn, T., Bown, S.G., Bigio, I.J. & Keshtgar, M.R.S., “Scanning elastic scattering spectroscopy detects metastatic breast cancer in sentinel lymph nodes.,” Journal of biomedical optics, vol. 15, 2010, p. 047001.
S. Joshi, A. Ergin, M. Wang, R. Reif, J. Zhang, J.N. Bruce, I. J. Bigio, “Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy,” Journal of Neuro-Oncology (2010)
A. Curtis, K. Calabro, J.-R. Galarneau, I. J. Bigio, T. Krucker, “Temporal Variations of Skin Pigmentation in C57Bl/6 Mice Affect Optical Bioluminescence Quantitation,” Molecular Imaging and Biology (2010)

2009

Y. Zhu, T. Fearn, G. Mackenzie, B. Clark, J. M. Dunn, I. S. Bigio, S. G. Brown, L. B. Lovat, “Elastic scattering spectroscopy for detection of cancer risk in Barrett’s esophagus: experimental and clinical validation of error removal by orthogonal subtraction for increasing accuracy,” Journal of Biomedical Optics 14 (4), 044022 (2009)
Christine S. Mulvey, Carly A. Sherwood, Irving J. Bigio, “Wavelength-dependent backscattering measurements for quantitative real-time monitoring of apoptosis in living cells,”Journal of Biomedical Optics 14 (6), 064013 (2009)

2008

R. Georgescu, D. Khismatullin, R. G. Holt, J. L. Castagner, O. A’Amar and I. J. Bigio, “Design of a system to measure light scattering from individual cells excited by an acoustic wave,” Opt. Expr.16(6), 3496-3503 (2008)
R. Reif, M. S. Amorosino, K. W. Calabro, O. A’Amar, S. K. Singh and I. J. Bigio, “Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures,” J. Biomed. Opt. 13(1), 010502 (2008)

2007

I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, and L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” PNAS 104 (44), 17255-17260 (2007)
H. Fang, L. Qiu, E. Vitkin, M. M. Zaman, C. Andersson, S. Salahuddin, L. M. Kimerer, P. B. Cipolloni, M. D. Modell, B. S. Turner, S. E. Keates, I. Bigio, I. Itzkan, S. D. Freedman, R. Bansil, E. B. Hanlon, and L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy,” Applied Optics 46(10), 1760-1769 (2007)
C. S. Mulvey, A. L. Curtis, S. K. Singh and I. J. Bigio, “Elastic scattering spectroscopy as a diagnostic tool for apoptosis in cell cultures,” IEEE J. of Sel. Top. in Quant. Elect. 13(6), 1663-1670 (2007)
R. Reif, O. A’Amar and I. J. Bigio, “Analytical model of light reflectance for the extraction of the optical properties in small volumes of turbid media,” Applied Optics 46(29), 7317-7328 (2007)
R. Reif, M. Wang, S. Joshi, O. A’Amar and I. J. Bigio, “Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue,” J. Biomed. Opt. 12(3), 034036 (2007)
JL Castagner and IJ Bigio, “Particle sizing with a fast polar nephelometer,”Applied Optics 46: No. 4, 527-532 (2007)

2006

Jean-Luc Castagner and Irving J. Bigio, “Polar nephelometer based on a rotational confocal imaging setup” Applied Optics 45: No. 10, 2232-2239 (2006)
L B Lovat, K Johnson, G D Mackenzie, B R Clark, M R Novelli, S Davies, M O’Donovan, C Selvasekar, S M Thorpe, D Pickard, R Fitzgerald, T Fearn, J Bigio and SG Bown, “Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett’s oesophagus” Gut 2006;55:1078-1083 (2006).
Sharwani, a, Jerjes, W., Salih, V., Swinson, B., Bigio, I.J., El-Maaytah, M. & Hopper, C., “Assessment of oral premalignancy using elastic scattering spectroscopy.,” Oral oncology, vol. 42, Apr. 2006, pp. 343-9.
Anjan Dhar, DM, MRCP, Kristie S. Johnson, DPhil, Marco R. Novelli, PhD, FRCPath, Stephen G. Bown, MD, FRCP, Irving J. Bigio, PhD, Laurence B. Lovat, PhD, FRCP, Stuart L. Bloom, DM, FRCPPDF “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique”GASTROINTESTINAL ENDOSCOPY, Vol. 63 No. 2, 2579-261 (2006).

2004

IJ Bigio and SG Bown, “Spectroscopic sensing of cancer and cancer chemotherapy, current status of translational research,” Cancer Biology and Therapy 3, No. 3, 259-267 (2004).
O A’Amar, RD Ley, IJ Bigio, “Comparison between UV-visible and NIR elastic-scattering spectroscopy of chemically induced melanomas in an animal model,” Journal of Biomedical optics 9(6): 1320-1326 (2004).
KS Johnson, DW Chicken, DCO Pickard, AC Lee, G Briggs, M Falzon, IJ Bigio, MR Keshtgar, SG Bown, “Elastic scattering spectroscopy for intraoperative determination of sentinel lymph node status in the breast,” Journal of Biomedical optics 9(6): 1122-1128 (2004).O A’Amar, MS Hirsch, IJ Bigio, “Optimizing the probe geometry of elastic scattering spectroscopy for the diagnosis of prostate cancer”, Biomedical Optics conference of the Optical Society of America in Miami Beach, Florida (2004).

2003

IJ Bigio, O A’Amar, MS Hirsch, “Elastic scattering spectroscopy for detection of prostate cancer: preliminary feasibility study”, Diagnostic Optical Spectroscopy in Biomedicine II, Proc. SPIE5141: 142-146 (2003).

2002

Ousama M A’Amar and Irving J Bigio, “Correction of fluorescence spectra using data from elastic scattering spectroscopy and a modified Beer’s law.”Optical Society of America Topical Meetings, Miami (2002).

2001

O A’Amar, R Ley, P Ripley, I Bigio, “In-vivo diagnosis of chemically induced melanoma in an animal model using UV-visible and NIR elastic-scattering spectroscopy: preliminary testing,” Proc. SPIE: Biomedical Diagnostic, Guidance and Surgical-Assist Systems, Proc. SPIE 4254: 144-150 (2001).

2000

I. J. Bigio, S.G. Bown, G. Briggs, S. Lakhani, D. Pickard, P.M. Ripley, I.G. Rose and C. Saunders “Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results” Journal of Biomedical Optics 5: 221-228 (2000)

1999

E Bossu, JJ Padilla, O A’Amar, RM Parache, D Notter, C Vigneron, F Guillemin, “Determination of endogenous porphyrins and the maximal HpD tumor/normal skin ratio in SKH-1 hairless mice by light induced fluorescence spectroscopy,” Artificial Cells Blood Substitutes and Immobilization Biotechnology 27(2): 109-117 (1999).
Judith R. Mourant, Tamara M. Johnson, Gerrit Los, Irving J. Bigio, “Noninvasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements” Journal of Physics in Medicine and Biology 44:1397-1417 (1999)

1998

H Rezzoug, L Bezdetnaya, O A’Amar, M Barberi-Heyob, JL Merlin, F. Guillemin, “Parameters affecting photodynamic activity of Foscan® or meta-tetra (hydroxyphenyl) chlorin (mTHPC) in vitro and in vivo,” Lasers in Medical Science 13(2): 119-125 (1998).

1997

Irving J. Bigio, Judith R. Mourant “Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy” Journal of Physics in Medicine and Biology 42: 803-814 (1997)
A.H. Hielscher, J.R. Mourant, I. J. Bigio, “Influence of particle size and concentration on the diffuse backscattering of polarized light from tissue phantoms and biological cell suspensions” Applied Optics 36: 125-135 (1997)J. R. Mourant, T. Fuselier, J. Boyer, T. Johnson, I. J. Bigio, “Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms” Applied Optics36: 949-957 (1997)
E Bossu, O A’Amar, RM Parache, D Notter, P Labrude, C Vigneron, F Guillemin, “Determination of the maximal tumor/normal skin ratio after HpD or m-THPC administration in hairless mouse (Skh-1) by fluorescence spectroscopy, a non invasive method,” Anti-Cancer Drugs 8: 67-72 (1997).
Judith R. Mourant, Irving J. Bigio, Darren A. Jack, Tamara M. Johnson, and Heather D. Miller, “Measuring absorption coefficients in small volumes of highly scattering media: source-detector separations for which path lengths do not depend on scattering properties,” Applied Optics 36: 5655-5661 (1997).

1996