Collaborative Research Discovers New Approach in the Treatment of Liver Cancer
Until now, there has been no effective, systemic treatment for liver cancer (hepatocellular carcinoma), the fifth most common cancer worldwide. Writing in the Proceedings of the National Academy of Science (PNAS), Professor Scott Schaus (Chemistry) and Professor Ulla Hansen (Biology and Molecular Biology, Cell Biology & Biochemistry) have reported their discovery of a new protein […]
Schaus & Virus Research Featured in ScienceDaily
ScienceDaily, has featured the research of a team of Boston University scientists in which they identified a novel compound that inhibits viruses from replicating. The findings, which were published online in the Journal of Virology, could lead to the development of highly targeted compounds to block the replication of poxviruses, such as the emerging infectious […]
CMLD Researchers Publish Paper on “Remodeling” Natural Products in Nature Chemistry
CMLD-BU researchers Bradley Balthaser, Meghan Maloney, Aaron Beeler, John Porco & John Snyder, in a paper published in the journal Nature Chemistry [23 OCTOBER 2011 | DOI: 10.1038/NCHEM.1178], present a new approach to accessing new, biorelevant structures by “remodeling” natural products. In this case, they demonstrate how the natural product derivative fumagillol can been remodeled […]
CMLD Symposium 2011
The Boston University Center for Chemical Methodology & Library Development (CMLD) will host their 12th Annual Symposium, Chemical Synthesis: Advances and Applications, on Friday, June 24th, 2011 at the Boston University Photonics Center. The speakers are: Professor Jef K. DeBrabander, University of Texas Southwestern Medical Center Natural Products: An Opportunity for Discovery Professor Wilfred A. […]
NIGMS Renews Funding for the CMLD-BU
The National Institute of General Medical Sciences (NIGMS) is continuing its support of the CMLD-BU as one of five Centers of Excellence addressing the problem of how to develop small molecule libraries and techniques for making them that meet all the needs of pharmaceutical and biomedical scientists. The CMLD-BU was originally established in 2002. The […]
CMLD-BU Scientists Awarded National Institutes of Health Grant in Pilot-Scale Libraries for High-Throughput Screening Program
Co-investigators of the Boston University Chemical Methodology and Library Development Center (CMLD-BU) (http://cmld.bu.edu) have been awarded a three-year grant for their joint proposal “Generation of Stereochemically and Structurally Complex Chemical Libraries.” The goal of the work by Professors Porco, and co-Principal Investigators Panek, Schaus, and Snyder, is to generate a number of stereochemically and structurally […]