PNAS

Reinhard Research Provides Insights into HIV-1

Recently reported in PNAS, Bjoern Reinhard and his collaborator at the BU Medical School, Dr. Suryaram Gummuluru, have confirmed a unique HIV-1 DC attachment mechanism using lipoparticles with defined surface composition. The  mechanism is dependent on a host-cell–derived ligand, GM3, and is a unique example of pathogen mimicry of host-cell recognition pathways that drive virus […]

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Collaborative Research Discovers New Approach in the Treatment of Liver Cancer

Until now, there has been no effective, systemic treatment for liver cancer (hepatocellular carcinoma), the fifth most common cancer worldwide. Writing in the Proceedings of the National Academy of Science (PNAS), Professor Scott Schaus (Chemistry) and Professor Ulla Hansen (Biology and Molecular Biology, Cell Biology & Biochemistry) have reported their discovery of a new protein […]

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Drug Mechanism of Action Using Bioinformatic Pathway Analysis

Professor Scott Schaus and Graduate Student Lisa Christadore are co-authors of: Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis Published in PNAS in July 2011, the paper represents their collaborative work with researchers in the BU Department of Mathematics and Statistics, Professor Eric Kolaczyk and Graduate Student Lisa Pham. It reports […]

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