Targeting calcium crystal deposits could help relieve pain (Boston)— Knee osteoarthritis (OA) is the most common form of arthritis, affecting approximately 600 million people worldwide and 34 million people in the U.S. There are no treatments available that prevent its progression to date. Recommended pharmacological treatments for symptoms have either small-to moderate effects or short-term […]
One in six cases have a distinct distribution of disease, clinical profile (Boston)—Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease defined by abnormal tau protein accumulating in a particular pattern in specific regions of the brain. Studies to-date suggest CTE begins in the outermost layer of the frontal lobe, the neocortex, where it then spreads […]
Transformation in medical training will contribute to a higher caliber of physicians, increase the quality of healthcare (Boston)—Traditional medical school curriculum consists of two years spent learning basic science followed by two years learning to apply such knowledge in the clinical realm. Though effective at delivering a massive volume of information in a short time, […]
(Boston)— Attempted suicide is one of the most significant predictors of completed suicide, which is becoming a leading cause of mortality in the U.S., especially among young adults. While prior research has focused mainly on individual-level risk factors for suicide–-such as psychiatric diagnoses, impulsiveness, substance use, previous suicide attempts—there is little information on risk factors […]
Findings provide crucial insights into diagnosing CTE in the living. (Boston)—Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease defined by hyperphosphorylated tau (p-tau) protein accumulating in a particular pattern in specific regions of the brain. Currently, CTE can only be diagnosed at autopsy. Like similar brain diseases, the clinical symptoms in life of people diagnosed […]
Findings may have far-reaching implications for the responsiveness of cancers to epigenetic therapies (Boston)—One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures. In cases of melanoma, the main targeted therapeutic strategy is directed against the mitogen-activated […]
(Boston)—Sabrina A. Assoumou, MD, MPH, the inaugural Louis W. Sullivan, MD, Professor of Medicine, and an associate professor of medicine at Boston University Chobanian and Avedisian School of Medicine, has been selected to serve in the 2024-2026 cohort of New Voices in Sciences, Engineering, and Medicine at the National Academies. Participants are selected in recognition […]
Timing of the initial whole blood transfusion, down to the minute, is connected to survival (Boston)—Significant bleeding due to traumatic injury is the number one cause of preventable deaths in the U.S., with the majority of deaths occurring within six hours. Emerging evidence suggests that the transfusion of whole blood (blood that is not separated […]
(Boston)—Cardiovascular disease (CVD) is the leading cause of death in the United States. Black women have a disproportionally higher burden of coronary heart disease (CHD) and CHD-related mortality and earlier onset than women of other racial and ethnic groups. Myocardial infarctions (MI), or heart attacks, also occur at younger ages in Black women and these […]
Findings may lead to therapies, cure (Boston)—Childhood interstitial lung disease (chILD) is a group of rare, genetic lung disorders affecting infants and children who typically present with a range of symptoms, such as shortness of breath, rapid breathing and coughing. While many causal genes have been identified for chILD, understanding its pathogenesis has been impeded […]