Boston University Thrombotic Microangiopathy Collaborative (BU-TMAC)

Multidisciplinary Patient Care, Research & Education

Advancing Diagnosis, Treatment, and Knowledge of TMA Syndromes

The Boston University Thrombotic Microangiopathy Collaborative (BU-TMAC) provides a multidisciplinary approach to the care of patients with TMA. The multidisciplinary team is very unique in its structure and function, involving physicians from different subspecialties with great interest and expertise in managing patients with TMA.

The Collaborative combines basic and clinical research to advance the understanding of the TMA syndromes. We are an integral part of the Affinity Research Collaborative (ARC) on Thrombosis and Homeostasis that consists of investigators from several academic departments with a common goal to investigate thrombosis in humans.

Our Mission Includes:

  • Evaluation, management, and treatment of patients with TMA.
  • To educate other health providers and increase awareness of the TMA syndromes.
  • Center for clinical trials and basic research on TMA syndromes.
  • Role model for the management of patients with TMA through a multidisciplinary team approach.

TMA Algorithm

*The information contained on this website is for general information purposes only – Diagnostic Algorithm.

Award & Recognition

BU-TMAC Logo

Congratulations to Dr. Francis for receiving the National Kidney Foundation New England Award – Excellence In Transplant and Nephrology.

Dr. Jean Francis

Jean Francis, MD
Medical Director of Kidney Transplantation (BUMC)
Associate Professor of Medicine (BUSM)
Medical Director of Pancreas Transplant Program, Brigham and Women Hospital
Associate Physician, Brigham and Women HospitalFor more information, visit the NKF website.
Meet BU-TMAC Team

Dr. Jean Francis

Dr. Jean Francis
Co-Director
Associate Professor (BUSM)
Nephrology

Dr. Mark Sloan

Dr. Mark Sloan
Co-Director
Associate Professor (BUSM)
Hematology & Medical Oncology

Dr. Laurence Beck

Laurence H. Beck Jr, MD, PhD
Associate Professor (BUSM)
Nephrology

Dr. Reggie Thomasson

Reggie Thomasson, MD
Assistant Professor (BUSM)
Pathology & Laboratory Medicine

Justine E. Dickson

Justine E. Dickson, PharmD
Pharmacy Clinical Specialist
Renal Transplant / TMA

Michael R. York

Michael R. York, MD
Assistant Professor (BUSM)
Rheumatology

Dr. Vipul Chitalia

Dr. Vipul Chitalia
Core Member, TMA Research Program
Associate Professor (BUSM)
Nephrology

Dr. Katya Ravid

Dr. Katya Ravid
Professor of Medicine (BUSM)
Cardiovascular Medicine

Dr. David Salant

Dr. David Salant
Professor (BUSM)
Nephrology

 

BU-TMAC Research
TMA and COVID-19
Patients Frequently Asked Questions
What types of TMA syndromes do you treat at BU-TMAC?
We manage all types of TMA syndromes regardless of the underlying cause — including acute, chronic, primary, and secondary TMA. Contact us to schedule an appointment.
What will happen on my visit?
Before your visit, we review your medical records. You’ll meet members of our TMA team who will evaluate and discuss a care plan based on multidisciplinary input.
Can I still see my current physician?
Yes, our care can complement your existing treatment. We coordinate closely with your doctors and maintain open communication throughout your care.
How do I schedule an appointment?
Contact Dr. Jean Francis at Jean.Francis@bmc.org or Dr. Vipul Chitalia at Vipul.Chitalia@bmc.org.
Important Publications
Napoleon MA, Yang X, Zhang Y, Morrissey A, Krinsky S, Francis J. et al.
Activation and targetability of TYMP-IL-6-TF signaling in the skin microenvironment in uremic calciphylaxis. Sci Transl Med. 2025 Apr 23;17(795):eadn5772. PMID: 40267216
Trivin-Avillach C, Jaberi A, Henderson JM, Beck LH, Francis J. Eculizumab
Use in Scleroderma Renal Crisis With Thrombotic Microangiopathy: A Case Report.
Kidney Med. 2024 Jan; 6. PMID: 38225975
Singh P, Chen H, Gordon CE, Ghai S, Sloan JM, et al.
Monoclonal IgG4/2? Deposition Following Eculizumab Therapy
Kidney Med. 2019 May-Jun; 1(3):139-143. PMID: 32734194
Kamel MH, Jaberi A, Gordon CE, Beck LH, Francis J.
The Complement System in the Modern Era of Kidney Transplantation
Semin Nephrol. 2022 Jan; 42(1):14-28. PMID: 35618392
Haddad G, Lorenzen JM, Ma H, et al.
Altered glycosylation of lgG4 in membranous nephropathy
J Clin Invest. 2021;131(5):e140453. Full Text
Kamel MH, Yin W, Zavaro C, Francis JM, Chitalia VC.
Hyperthrombotic Milieu in COVID-19 Patients
Cells. 2020 Oct 31; 9(11). PMID: 33142844
Reddy YN, Siedlecki AM, Francis JM.
Breaking down the complement system
Curr Opin Nephrol Hypertens. 2017 Mar; 26(2):123-128. PMID: 27977428
Gordon CE, Chitalia VC, Sloan JM, Salant DJ, et al.
Thrombotic Microangiopathy: A Multidisciplinary Team Approach
Am J Kidney Dis. 2017 Nov; 70(5):715-721. PMID: 28720207