BU Pharmacology & Experimental Therapeutics-Pfizer Symposium:Emerging Technologies in Therapeutics

BU Trustees Ballroom, 9th Floor, 1 Silber Way, Boston, MA 02215 Free and Open to the Public.  Registration Required: http://www.bumc.bu.edu/busm-pm/bupfizeremergingtechnologies/ Parking: Kenmore Lot, 549 Commonwealth Avenue or Granby Lot, 665 Commonwealth Avenue Accessible by Public Transportation: Via the Green Line B Line – Exit at Blandford Street Symposium Schedule: 8:00 - 8:30     Registration and Breakfast 8:30 - 8:40     INTRODUCTION TO THE BU - PFIZER DOCTORAL TRAINING PARTNERSHIP - David H. Farb, PhD, Chair BU Pharmacology and Director, NIGMS Program in Biomolecular Pharmacology; Lori Fitz, PhD, Precision Medicine Scientist and Laboratory Head, Pfizer and 2006 Graduate of the BU Program in Biomolecular Pharmacology 8:40 - 10:10   SESSION 1    CYTOSOLIC DNA SENSORS AND DEATH       PATHWAYS - Moderator: Rachel L. Flynn PhD, Assistant Professor, Pharmacology, BU     RIPK1 in Necroptosis and Axonal Degeneration: From Basic Cell Death to Human Clinical Applications - Junying Yuan, PhD, Elizabeth D. Hay Professor of Cell Biology, Harvard Medical School Receptor Interacting Protein Kinases: Integrating Cell Death and Inflammation Signals - Francis Ka-Ming Chan, PhD, Professor of Pathology, University of Massachusetts Medical School To the Edge of Necroptosis and Back - Douglas R. Green, PhD, Peter C. Doherty Endowed Chair in Immunology, St. Jude Children's Research Hospital 10:40 -12:00  SESSION 2     THE UNFOLDED PROTEIN - Moderator: Hui Feng, MD, PhD, Assistant Professor of Pharmacology, BU Protein MIsfolding in the Endoplasmic Reticulum and Oxidative Stress Initiate Liver Failure in Non-Alcoholic Steatohepatitis (NASH) - Randal J. Kaufman, PhD, Director, Degenerative Disease Program and Endowed Chair in Cell Biology, Sanford Burnham Presby Medical Discovery Institute Targeting the Unfolded Protein Response in Pancreatic Neuroendocrine Tumors - Scott A. Oakes, MD, Professor of Pathology, University of California San Francisco School of Medicine A Mitochondrial Stress Response and Propagation of Toxic Genomes - Cole Haynes, PhD, Associate Professor of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School 12:00 - 1:00    Lunch 1:00 - 2:20   SESSION 3     PHARMACOLOGY AS A CENTRAL DISCIPLINE FOR DRUG DISCOVERY - Moderator: Camron D. Bryant, PhD, Assistant Professor of Pharmacology, BU EDUCATION: Pharmacology in a Changing Therapeutic Landscape - Marion Kasaian, PhD, Inflammation and Immunology, Pfizer DISCOVERY: Learning from Tofacitinib, a JAK Inhibitor for Autoimmune Disease - James D. Clark, PhD, Director, Inflammation and Immunology, Pfizer PHARMACOLOGY IN CLINICAL TRIALS AND DRUG DISCOVERY - Gianluca Nucci, PhD, VP, Early Development/Clinical Pharmacology, Pfizer 2:40 - 3:40   SESSION 4    INNOVATION IN CANCER THERAPEUTICS - Moderator: David Peritt, PhD, Research Project Leader, Inflammation and Immunology, Pfizer Gene and Oncolytics Immunotherapy Clinical Trials for Glioblastoma - E. Antonio Chiocca, MD, PhD, Harvey Cushing Professor of Neurosurgery, Harvard Medical School; Chairman, Department of Neurosurgery, Brigham and Women's Hospital Replicating Virus Therapeutics for the Treatment of Cancer - John C. Bell, PhD, Senior Scientist, Centre for Innovative Cancer Research, Ottawa Hospital Research Institute; Professor, Departments of Medicine and Biochemistry, Microbiology & Immunology, University of Ottawa 3:40 - 4:10    BUSM ALUMNUS KEYNOTE ADDRESS - Polymeric Nanoparticles: Tumor Microenvironment Variability and Implications for New Nanoparticle Design and Development - Omid C. Farokhzad, MD (BUSM '99), Associate Professor, Harvard Medical School; Director, Center for Nanomedicine, Department of Anesthesiology, Preoperative and Pain Medicine, Brigham and Women's Hospital. 4:10 - 4:40   Open Forum - Moderator: William Gordon, PhD, Senior Principal Scientist and Disease Pathogenesis Lead, Pfizer 4:40 - 4:45    Closing Remarks - David H. Farb, PhD 4:45 - 6:00    Reception