Masters Thesis Final Defense: Francini Luna

MSE Masters Thesis Final Defense: Francini Luna

TITLE: Designing a braided bioabsorbable magnesium metal stent

ADVISOR: Sheila Russo MSE, ME

COMMITTEE: James Scutti Boston Scientific; Lauren Lydecker Boston Scientific

ABSTRACT: Bioabsorbable biliary stents, made from magnesium, zinc or iron, offer a promising solution to address complications of traditional stents, such as inflammation and recurrent procedures. This study focused on developing a braided bioabsorbable stent made out of Magnesium alloy WE22, developing and optimizing the braiding process, and characterizing the stents’ degradation profile. The mechanical properties of WE22 wires were first characterized through tensile testing to ensure sufficient strength and flexibility for stent braiding and deployment. The testing informed process parameters such as wire drawing and annealing, achieving an optimal balance between durability and elasticity to prevent fracture during fabrication. The stents were braided using a controlled process to optimize braid angle, wire tension, and density. Iterative adjustments ensured uniformity, essential for maintaining integrity during implantation. Degradation studies were conducted in simulated bile and intestinal fluids to assess the stents’ degradation. The degradation profile was evaluated by monitoring weight loss, pH changes, and visual changes over time. The findings demonstrate the feasibility of WE22 braided stents, offering temporary support with predictable degradation, making them suitable for gastrointestinal and biliary applications.