Publications

Reviews, Perspectives, & Book Chapters:

9. J.A. White, R.J. Butera Jr., B. Choi, M.J. Dunlop, A.L. Lerner, R.A. Linsenmeier, L.G. Gilbertson, K.J. Grande-Allen, A. Grosberg, R.W. Hitchcock, A.Y. Huang-Saad, M. Kotche, A.M. Kyle, J.H. Linehan, M.I. Miller, J.A. Papin, L. Setton, A. Sgro, M.L. Smith, M. Zaman, A.P. Lee. 2020. Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations. Ann Biomed Eng. 48: 905-12.

8. G.A. Hoffmann, M.L Smith. 2019. New Insights into Collagen and Fibronectin Reciprocity during Extracellular Matrix Formation. Chem. doi: 10.1016/j.chempr.2019.07.012

7. G.A. Hoffmann, J.Y.Wong, M.L. Smith. 2019. On Force and Form: Mechano-Biochemical Regulation of Extracellular Matrix. Biochemistry. doi: 10.1021/acs.biochem.9b00219

6. A.J. Zollinger, M.L. Smith. 2016. Fibronectin, the extracellular glue. Matrix Biol. In Press, available online 3 August 2016.

5. S.R. Polio, M.L. Smith. 2014. Patterning and image processing for traction force microscopy. Methods Cell Biol. 121: 17-31.

4. C.K. Kuo, M.L. Smith. 2014. Biomaterial design motivated by characterization of natural extracellular matrices. MRS Bull. 39(1): 18-24.

3.  M.J. Bradshaw, M.L. Smith. 2014. Multiscale relationships between fibronectin structure and biological function. Acta Biomater. 10(4): 1524-31.

2. V.P. Hytönen, M.L. Smith, V. Vogel. 2010. Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues. Chapter 13: Translating mechanical force into discrete biochemical signal changes: multimodularity imposes unique properties to mechanotransductive proteins. (Editors: Mohammad Mofrad and Roger Kamm). Cambridge University Press.

1.  M.R. Dusseiller, M.L. Smith, V. Vogel, M. Textor. 2006. Microfabricated three-dimensional environments for single cell studies. Biointerphases. 1(1): 1-4.

Peer Reviewed Research Articles:

43. Stamenović, R. Krishnan, E.P. Canović, M.L. Smith. 2020. As the endothelial cell reorients, its tensile forces stabilize. J Biomech. In Press.

42. J. Li, P.E. Barbone, M.L. Smith, D. Stamenović. 2020. Effect of correlation between traction forces on tensional homeostasis in clusters of endothelial cells and fibroblasts. J Biomech. 100: 109588-91.

41. M.J. Bradshaw, G. Hoffmann, J.Y. Wong, M.L. Smith. 2019. Fibronectin fiber creep under constant force loading. Acta Biomater. 88: 78-85.

40. O.E. Onochie, A. Zollinger, C.B. Rich, M. Smith, V. Trinkaus-Randall. 2019. Epithelial cells exert differential traction stress in response to substrate stiffness. Exp Eye Res. 181: 25-37.

39. A.J. Zollinger, H. Xu, J. Figueiredo, J. Paredes, R. Seruca, D. Stamenović, M.L. Smith. 2018. Dependence of tensional homeostasis on cell type and on cell-cell interactions. Cell Mol Bioeng. 11(3): 175-84.

38. M.M. Jacobsen, D. Li, N.G. Rim, D. Backman, M.L. Smith, J.Y. Wong. 2017. Silk-fibronectin alloy fiber for improved cellular adhesion. Sci Rep. 7: 45653.

37. D.R. Myers, Y. Qiu, M.E. Fay, M. Tennenbaum, D. Chester, J. Cuadrado, Y. Sakurai, J. Baek, R. Tran, J.C. Ciciliano, B. Ahn, R.G. Nammino, S.T. Bunting, C. Bennett, M. Briones, A. Fernandez-Nieves, M.L. Smith, A.C. Brown, T. Sulchek, W.A. Lam. 2017. Single-platelet nanomechanics measured by high-throughput cytometry. Nat Mater. 16: 230-35.

36. S.N. Tam, M.L. Smith, D. Stamenović. 2017. Modeling tensional homeostasis in multicellular clusters. Int J Numer Method Biomed Eng. 33(3): e02801.

35. E.P. Canović, A.J. Zollinger, S.N. Tam, M.L. Smith, D. Stamenović. 2016. Tensional homeostasis in endothelial cells is a multicellular phenomenon. Am J Physiol Cell Physiol. 311(3): C528-35. Note: This article was selected for inclusion in APSselect, a collection from all APS journals that showcases some of the best recently published articles in physiological research.

34. B. Hubbard, J.A. Buczek-Thomas, M.A. Nugent, M.L. Smith. 2016. Fibronectin fiber extension decreases cell spreading and migration. J Cell Physiol. 231(8): 1728-36. Note: Featured as a JCP Spotlight Article.

33. K.E. Kubow, R. Vukmirovic, L. Zhe, E. Klotzsch, M.L. Smith, D. Gourdon, V. Vogel. 2015. Mechanical forces regulate the interactions of two prominent extracellular matrix proteins: fibronectin and collagen. Nat Commun. 6: 8026.

32. E.P. Canović, D.T. Seidl, P.E. Barbone, M.L. Smith, D. Stamenović. 2014. Stiffness versus prestress relationship at subcellular length scale. J Biomech. 47: 3222-5.

31. S.R. Polio, H. Parameswaran, E.P. Canović, C. Gaut, D. Aksyonova, D. Stamenović, M.L. Smith. 2014. Topographical control of multiple cell adhesion ligands for traction force microscopy. Integr Biol. 6(3): 357-65. Note: Featured as a HOT article by Integrative Biology.

30. B. Hubbard, J.A. Buczek-Thomas, M.A. Nugent, M.L. Smith. 2014. Heparin-dependent regulation of fibronectin matrix conformation. Matrix Biol. 34: 124-31.

29. E.P. Canović, D.T. Seidl, S.R. Polio, A.A. Oberai, P.E. Barbone, D. Stamenović, M.L. Smith. 2014. Biomechanical imaging of cell stiffness and prestress with subcellular resolution. Biomech Model Mechanobiol. 13: 665-78. Note: Canović was awarded the 2013 BME Graduate Student Paper of the Year Award for this publication.

28. M.J. Bradshaw, M.C. Cheung, D.J. Ehrlich, M.L. Smith. 2012. Using molecular mechanics to predict bulk material properties of fibronectin fibers. PLoS Comput Biol. 8(12): e1002845.

27. R. Krishnan, E.P. Canović, A.L. Iordan, K. Rajendran, G. Manomohan, A.P. Pirentis, M.L. Smith, J.P. Butler, J.J. Fredberg, D. Stamenović. 2012. Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches. Am J Physiol Cell Physiol. 303(4): C368-75.

26. S.R. Polio, K.E. Rothenberg, D. Stamenović, M.L. Smith. 2012. A micropatterning and image processing approach to simplify measurement of cellular traction forces. Acta Biomater. 8(1): 82-8.

25. M.J. Bradshaw, M.L. Smith. 2011. Contribution of unfolding and intermolecular architecture to fibronectin fiber extensibility. Biophys J. 101(7): 1740-8.

24. M. Andreasson-Ochsner, G. Romano, M. Håkanson, M.L. Smith, D.E. Leckband, M. Textor, E. Reimhult. 2011. Single cell 3-D platform to study ligand mobility in cell-cell contact. Lab Chip. 11(17): 2876-83.

23. M. Chabria, S. Hertig, M.L. Smith, V. Vogel. 2010. Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope. Nat Commun. 1(9): 135.

22. M. Ochsner, M. Textor, V. Vogel, M.L. Smith. 2010. Dimensionality controls cytoskeleton assembly and metabolism of fibroblast cells in response to rigidity and shape. PLoS One. 5(3): e9445.

21. M. Rottmar, M. Hakanson, M. Smith, K. Maniura-Weber. 2010. Stem cell plasticity, osteogenic differentiation and the third dimension. J Mater Sci Mater Med. 21(3): 999-1004.

20. K.E. Kubow, E. Klotzsch, M.L. Smith, D. Gourdon, W.C. Little, V. Vogel. 2009. Crosslinking of cell-derived 3D matrices upregulates the stretching and unfolding of new ECM assembled by reseeded fibroblasts. Integr Biol. 1(11-12): 635-48.

19. E. Klotzsch, M.L. Smith, K.E. Kubow, S. Muntwyler, W.C. Little, F. Beyeler, D. Gourdon, B.J. Nelson, V. Vogel. 2009. Fibronectin forms the most extensible biological fibers displaying force-exposed cryptic binding sites. Proc Natl Acad Sci USA. 106(43): 18267-72.

18. W. Little, R. Schwartlaender, M.L. Smith, D. Gourdon, V. Vogel. 2009. Stretched extracellular matrix proteins turn fouling and are functionally rescued by the chaperones albumin and casein. Nano Lett. 9(12): 4158-67.

17. A.J. Meinel, K.E. Kubow, E. Klotzsch, M. Garcia-Fuentes, M.L. Smith, V. Vogel, H.P. Merkle, L. Meinel. 2009. Optimization strategies for electrospun silk fibroin tissue engineering scaffolds. Biomaterials. 30(17): 3058-67.

16. W. Little, M.L. Smith, U. Ebneter, V. Vogel. 2008. Assay to mechanically tune and optically probe fibrillar fibronectin conformations from fully relaxed to breakage. Matrix Biol. 27: 451-61.

15. M.L. Smith, D. Gourdon, W. Little, K.E. Kubow, R. Andresen Eguiluz, S. Morris, V. Vogel. 2007. Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol. 5(10): e268.

14. M. Ochsner, M.R. Dusseiller, H.M. Grandin, S. Morris, M. Textor, V. Vogel, M.L. Smith. 2007. Micro-well arrays for 3D shape control and high resolution analysis of single cells. Lab Chip. 7(8): 1074-77.

13. M. Sperandio, D. Frommhold, I. Babushkina, L.G. Ellies, T.S. Olson, M.L. Smith, B. Fritzsching, E. Pauly, D.F. Smith, R. Nobiling, O. Linderkamp, J.D. Marth, K. Ley. 2006. a2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation. Eur J Immunol. 36(12):3207-15.

12. B.C. Chesnutt, D.F. Smith, N.A. Raffler, M.L. Smith, E.J. White, K. Ley. 2006. Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin. Microcirculation. 13(2): 99-109.

11. P. Koszalka, B. Ozuyaman, Y. Huo, A. Zernecke, U. Flogel, N. Braun, A. Buchheiser, U.K. Decking, M.L. Smith, J. Sevigny, A. Gear, A.A. Weber, A. Molojavyi, Z. Ding, C. Weber, K. Ley, H. Zimmermann, A. Godecke, J. Schrader. 2004. Targeted disruption of cd73/Ecto-5′-Nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res. 95(8): 814-21.

10. M.L. Smith, M. Sperandio, E.V. Galkina, K. Ley. 2004. Autoperfused flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin. J Leukoc Biol. 76(5): 985-93.

9. M.L. Smith, T.S. Olson, K. Ley. 2004. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med. 200(7): 935-39.

8. E.R. Damiano, D.S. Long, M.L. Smith. 2004. Estimation of viscosity profiles using velocimetry data from parallel flows of linearly viscous fluids: Application to microvascular hemodynamics. J Fluid Mech. 512: 1-19.

7. D.S. Long, M.L. Smith, A.R. Pries, K. Ley, E.R. Damiano. 2004. Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution. Proc Natl Acad Sci USA. 101(27): 10060-65.

6. M. Sperandio, M.L. Smith, S.B. Forlow, T.S. Olson, L. Xia, R.P. McEver, K. Ley. 2003. P-selectin Glycoprotein Ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J Exp Med. 197(10): 1355-63.

5. M.L. Smith, D.S. Long, E.R. Damiano, K. Ley. 2003. Near-wall m-PIV reveals the presence of a hemodynamically relevant endothelial surface layer in venules in vivo. Biophys J. 85: 637-45.

4. H.Y. Shin, M.L. Smith, K.J. Toy, P.M. Williams, R. Bizios, M.E. Gerritsen. 2002. VEGF-C mediates cyclic pressure-induced endothelial cell proliferation. Physiol Genomics. 11(3): 245-51.

3. M.L. Smith, M.J. Smith, M.B. Lawrence, K. Ley. 2002. Viscosity independent velocity of neutrophils rolling on P-selectin in vitro or in vivo. Microcirculation. 9: 523-36.

2. L.G. Ellies, M. Sperandio, G.H. Underhill, J. Yousef, M. Smith, J.J. Priatel, G. Kansas, K. Ley, J.D. Marth. 2002. Sialyltransferase specificity in selectin ligand formation. Blood. 100(10): 3618-25.

1. K. Singbartl, J. Thatte, M.L. Smith, K. Wethmar, K. Day, K. Ley. 2001. A CD2-GFP transgenic mouse reveals VLA-4-dependent CD8+ lymphocyte rolling in inflamed venules. J Immunol. 166(12): 7520-26.

 

Select Conference Posters and Presentations:

16. G.A. Hoffmann, M.M. Jacobsen, M.D. Layne, J.Y. Wong, M.L. Smith, Mechanically active and tunable extracellular matrix fibers for tissue engineering applications. Multiscale Mechanochemistry & Mechanobiology Conference; Montreal, Canada, July 30, 2019

15. *H. Xu, A.J. Zollinger, J. Paredes, R. Seruca, D. Stamenović, M.L. Smith, Cellular Tensional Homeostasis Depends on Cell Type and on Cell-Cell Interactions. Gordon Research Conference: Signaling by Adhesion Receptors; Biddeford, ME, June 28, 2018

14. *G.A. Hoffmann, M.M. Jacobsen, M.D. Layne, J.Y. Wong & M.L. Smith, Protein properties determine characteristics of wet spun protein fibers. Signaling by Adhesion Receptors Gordon Research Conference; Biddeford, ME. Jun 28, 2018

13. *H. Xu, J. Figueiredo, J. Paredes, R. Seruca, M.L. Smith and D. Stamenović, Site-specific E-cadherin Mutations Affect Gastric Cancer Cell Tensional Homeostasis. BMES; Pheonix, AZ. Oct 11, 2017

12. *H. Xu, J. Figueiredo, J. Paredes, R. Seruca, M.L. Smith and D. Stamenović. Effects of Mutated E-cadherin on Human Gastric Cancer Cell Tensional Homeostasis. SES; Boston, MA. August 27, 2017.

11. *A.J. Zollinger, H. Xu, M.L. Smith. Importance of Cell Type in Tensional Homeostasis. SES; Boston, MA. August 27, 2017.

10.  * M.M. Jacobsen, S. Anderson, J.Y. Wong, M.L. Smith. Fibronectin fiber extrusion via silk-inspired shear spinning. BMES; Minneapolis, MN. October 7, 2016.

9.  H. Xu, D. Stamenović, M.L. Smith. Effect of fluid shear stress on endothelial cell tensional homeostasis. BMES; Minneapolis, MN. October 7, 2016.

8.  A.J. Zollinger, E.P. Canović, M.L. Smith, D. Stamenović. Multicellular regulation of tensional homeostasis. BMES; Minneapolis, MN. October 7, 2016.

7. * H. Parameswaran, R. Krishnan, M.L. Smith, K.R. Lutchen. Cell-extracellular matrix interactions play a critical role in the origin of hyperreactivity of airway smooth muscle cells in asthma. BMES; Minneapolis, MN. October 7, 2016.

6.  M.L. Smith, B. Hubbard, M. Bradshaw, J.A. Buczek-Thomas, M. Nugent. Fibronectin fiber extension decreases cell spreading and migration. Gordon Research Conference (Signaling by Adhesion Receptors). Bates College in Lewiston, ME. June 22, 2016.

5. * M.M. Jacobsen, D. Li, N.G. Rim, D. Backman, M.L. Smith, J.Y. Wong. Microfluidic spinning of fibronectin fibers via silk-induced cross-linking. 10thWorld Biomaterials Congress; Montreal, Canada. May 20, 2016.

4. * S.N. Tam, M.L. Smith, D. Stamenović. Modeling tensional homeostasis in cells. BMES; Tampa, FL. October 10, 2015.

3. * D. Stamenović, E.P. Canović, A.J. Zollinger, S.N. Tam, M.L. Smith. Tensional homeostasis is a multicellular phenomenon. European Society of Biomechanics; Prague, Czech Republic. July 6, 2015.

2.  A.J. Zollinger, E.P. Canovic, S.N. Tam, M.L. Smith, D. Stamenovic. Role of Cell-cell interaction in tensional homeostasis. Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C). Snowbird, UT. June 17th, 2015.

1. * E.P. Canović, S.N. Tam, A.J. Zollinger, M.L. Smith, D. Stamenović. Multicellular regulation of tensional homeostasis. 4th International Conference on Computational and Mathematical Biomedical Engineering; Paris, France. June 30, 2015.