Coordinated Submission Opportunity: NIH Shared Instrumentation Grant (SIG) & High-End Instrumentation (HEI) Grant (S10 Clinical Trial Not Allowed) 2025
URLs:
SIG: https://grants.nih.gov/grants/guide/pa-files/PAR-24-265.html
HEI: https://grants.nih.gov/grants/guide/pa-files/PAR-24-264.html
OBJECTIVES
The objective of the Shared Instrumentation Grant (SIG) Program is to make available to institutions high-priced research instruments that can only be justified on a shared-use basis and that are needed for NIH-supported projects in basic, translational, or clinical biomedical and biobehavioral research. The SIG Program provides funds to purchase or upgrade a single item of expensive, state-of-the-art, specialized, commercially available instrument or an integrated instrumentation system. An integrated instrumentation system is one in which the components, when used in conjunction with one another, perform a function that no single component can provide. The components must be dedicated to the system and not used independently.
Types of supported instruments for SIG include, but are not limited to: X-ray diffractometers, mass spectrometers, nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, high throughput robotic screening systems, and biomedical imagers. Applications for standalone computer systems (supercomputers, computer clusters and data storage systems) will only be considered if the system is solely dedicated to biomedical research.
The objective of the High-End Instrumentation (HEI) Grant Program is to make available to institutions high-end research instruments that can only be justified on a shared-use basis and that are needed for NIH-supported projects in basic, translational, and clinical biomedical or biobehavioral research. The HEI program provides funds to purchase or upgrade a single item of expensive, leading-edge, specialized, commercially available instrument or an integrated instrumentation system. An integrated instrumentation system is one in which the components, when used in conjunction with one another, perform a function that no single component can provide. The components must be dedicated to the system and not used independently.
Types of supported instruments include, but are not limited to: MRI imagers, PET/CT imagers, cyclotrons, photoacoustic imagers, mass spectrometers, NMR spectrometers, electron microscopes, cryo-electron microscopes, X-ray diffractometers, and super-resolution microscopes. Applications for standalone computer systems (supercomputers, computer clusters and data storage systems) will only be considered if the system is solely dedicated to biomedical research.
FUNDING INFORMATION
Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. Awards are made for one year only. There is no upper limit on the cost of the instrument for either grant, but each award must fall within the following ranges:
For SIG: Between $50,000 and $750,000
For HEI: Between $750,001 and $2 million
ELIGIBILITY
BU may submit more than one application, provided that each application is scientifically distinct and there are no overlaps with existing SIG, HEI, or Basic Instrumentation Grant (BIG) types.
There are no restrictions on who may be a PD/PI for these grants. Multiple PDs/PIs are not allowed for these grants. The PD/PI should document (in the biographical sketch) technical expertise directly related to the type of requested instrument. The PD/PI does not need to have an NIH research grant or any other research support but is expected to be an expert on the requested instrument.
INTERNAL SELECTION PROCESS
Interested investigators should submit the following materials via InfoReady Review by: 4/21/2025
- Questions outlined in InfoReady Review application
- 2-page Grant Statement describing the PI’s scientific achievements and proposed instrumentation, including a description of the user base for the proposed instrumentation
- Up-to-date biosketch
A faculty committee will review internal applications and select nominees.
DEADLINES
Internal Materials Due: Monday, April 21, 2025 by 11:59 pm EDT
Anticipated Notification Date for Nominees: Wednesday, April 30, 2025
Sponsor Deadline: Monday, June 2, 2025 by 5:00 pm