Alexa S. Beiser, PhD
Professor, Biostatistics - Boston University School of Public Health
Biography
Alexa Beiser has been on the faculty at Boston University School of Public Health since 1985, engaged in teaching and collaborative public health research; she co-developed the doctoral program in biostatistics; co-directed the biostatistics program from 2000-2004, and served as Associate Chair for Education from 2015-2018. She formerly taught and coordinated the sections of Introduction to Statistical Computing. For more than twenty-five years, Dr. Beiser has served as the lead biostatistician for the Framingham Heart Study (FHS) neurology group, examining risk factors and prevalence and incidence of clinical and sub-clinical neurological outcomes including MRI and PET measures of brain structure, cognitive performance, dementia, Alzheimer’s disease, stroke, Parkinson’s disease, and epilepsy. Dr. Beiser currently leads the FHS neurology group data management team, responsible for surveillance and tracking of incident dementia, for supervision of recruitment of participants for various grant-funded studies, and for management of data collected at FHS as well as those measured or processed at other institutions (e.g., brain MRI or PET scans); and the FHS neurology group biostatistics team of six biostatisticians. Decades of examining risk factors for neurological diseases has naturally led to studying factors associated with accelerated brain aging. Dr. Beiser has coauthored FHS publications relating risk factors including midlife vascular factors, plasma homocysteine, plasma leptin levels, cardiac index, red blood cell omega-3 fatty acids, metabolic dysregulation, visceral fat, air pollution; serum brain-derived neurotrophic factor; and insulin-like growth factor 1, to measures of brain aging. Dr. Beiser also has made use of the richness of the multigenerational Framingham data to relate documented parental dementia and stroke to offspring stroke, cognitive performance, and MRI measures of brain structure. In investigations of clinical neurological endpoints, she has applied competing risk analyses and has also been able to investigate temporal trends in prevalent and incident neurological disease due to the availability of event surveillance over many decades. In all these studies, Dr. Beiser plays a key role in project conceptualization, is responsible for supervision of statistical data management, analysis, and interpretation of results, and contributes to manuscript preparation and critical review.
Other Positions
- Associate Chair, Biostatistics - Boston University School of Public Health
- Professor, Neurology - Boston University Chobanian & Avedisian School of Medicine
- Investigator - Framingham Heart Study
- - Boston Medical Center
Education
- Boston University, PhD Field of Study: Mathematics
- University of California, San Diego, MA Field of Study: Applied Mathematics
- University of California, Santa Cruz, BA Field of Study: Biology/Psychology
Websites
Publications
- Published on 7/22/2024
Gonzales MM, O'Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal CL, Decarli CS, Fakhri GE, Johnson KA, Beiser AS, Seshadri S, Pase M. Associations of cerebral amyloid beta and tau with cognition from midlife. Alzheimers Dement. 2024 Jul 22. PMID: 39039896.
Read At: PubMed
- Published on 7/1/2024
Mukadam N, Wolters FJ, Walsh S, Wallace L, Brayne C, Matthews FE, Sacuiu S, Skoog I, Seshadri S, Beiser A, Ghosh S, Livingston G. Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies. Lancet Public Health. 2024 Jul; 9(7):e443-e460. PMID: 38942556.
Read At: PubMed
- Published on 6/6/2024
Medved S, Salinas J, Kojis D, Weinstein G, Vasan RS, Beiser A, Seshadri S. The association between levels of brain-derived neurotrophic factor and comorbid depression in patients with cardiovascular disease: The Framingham Heart Study. Psychiatry Clin Neurosci. 2024 Aug; 78(8):438-445. PMID: 38842141.
Read At: PubMed
- Published on 5/3/2024
Knol MJ, Poot RA, Evans TE, Satizabal CL, Mishra A, Sargurupremraj M, van der Auwera S, Duperron MG, Jian X, Hostettler IC, van Dam-Nolen DHK, Lamballais S, Pawlak MA, Lewis CE, Carrion-Castillo A, van Erp TGM, Reinbold CS, Shin J, Scholz M, Håberg AK, Kämpe A, Li GHY, Avinun R, Atkins JR, Hsu FC, Amod AR, Lam M, Tsuchida A, Teunissen MWA, Aygün N, Patel Y, Liang D, Beiser AS, Beyer F, Bis JC, Bos D, Bryan RN, Bülow R, Caspers S, Catheline G, Cecil CAM, Dalvie S, Dartigues JF, DeCarli C, Enlund-Cerullo M, Ford JM, Franke B, Freedman BI, Friedrich N, Green MJ, Haworth S, Helmer C, Hoffmann P, Homuth G, Ikram MK, Jack CR, Jahanshad N, Jockwitz C, Kamatani Y, Knodt AR, Li S, Lim K, Longstreth WT, Macciardi F, Mäkitie O, Mazoyer B, Medland SE, Miyamoto S, Moebus S, Mosley TH, Muetzel R, Mühleisen TW, Nagata M, Nakahara S, Palmer ND, Pausova Z, Preda A, Quidé Y, Reay WR, Roshchupkin GV, Schmidt R, Schreiner PJ, Setoh K, Shapland CY, Sidney S, St Pourcain B, Stein JL, Tabara Y, Teumer A, Uhlmann A, van der Lugt A, Vernooij MW, Werring DJ, Windham BG, Witte AV, Wittfeld K, Yang Q, Yoshida K, Brunner HG, Le Grand Q, Sim K, Stein DJ, Bowden DW, Cairns MJ, Hariri AR, Cheung CL, Andersson S, Villringer A, Paus T, Cichon S, Calhoun VD, Crivello F, Launer LJ, White T, Koudstaal PJ, Houlden H, Fornage M, Matsuda F, Grabe HJ, Ikram MA, Debette S, Thompson PM, Seshadri S, Adams HHH. Genetic variants for head size share genes and pathways with cancer. Cell Rep Med. 2024 May 21; 5(5):101529. PMID: 38703765.
Read At: PubMed
- Published on 5/1/2024
Martirosian RA, Wiedner CD, Sanchez J, Mun KT, Marla K, Teran C, Thirion M, Liebeskind DS, McGrath ER, Zucker JM, Bernal R, Beiser AS, DeCarli C, Himali JJ, Seshadri S, Hinman JD. Association of Incident Stroke Risk With an IL-18-Centered Inflammatory Network Biomarker Composite. Stroke. 2024 Jun; 55(6):1601-1608. PMID: 38690658.
Read At: PubMed
- Published on 5/1/2024
Levine DA, Whitney RT, Ye W, Briceño EM, Gross AL, Giordani BJ, Sussman JB, Lazar RM, Howard VJ, Aparicio HJ, Beiser AS, Elkind MSV, Gottesman RF, Koton S, Pendlebury ST, Kollipara AS, Springer MV, Seshadri S, Romero JR, Fitzpatrick AL, Longstreth WT, Hayward RA. Associations Between Stroke Type, Ischemic Stroke Subtypes, and Post-Stroke Cognitive Trajectories. medRxiv. 2024 May 01. PMID: 38903102.
Read At: PubMed
- Published on 5/1/2024
DeCarli C, Maillard P, Pase MP, Beiser AS, Kojis D, Satizabal CL, Himali JJ, Aparicio HJ, Fletcher E, Seshadri S. Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants Born 1930 to 1970. JAMA Neurol. 2024 May 01; 81(5):471-480. PMID: 38526486.
Read At: PubMed
- Published on 4/2/2024
Kelly DM, Pinheiro AA, Koini M, Anderson CD, Aparicio H, Hofer E, Kern D, Blacker D, DeCarli C, Hwang SJ, Viswanathan A, Gonzales MM, Beiser AS, Seshadri S, Schmidt R, Demissie S, Romero JR. Impaired Kidney Function, Cerebral Small Vessel Disease and Cognitive Disorders: The Framingham Heart Study. Nephrol Dial Transplant. 2024 Apr 02. PMID: 38565317.
Read At: PubMed
- Published on 3/12/2024
Weinstein G, Kojis DJ, Ghosh S, Beiser AS, Seshadri S. Association of Neurotrophic Factors at Midlife With In Vivo Measures of ß-Amyloid and Tau Burden 15 Years Later in Dementia-Free Adults. Neurology. 2024 Apr 09; 102(7):e209198. PMID: 38471064.
Read At: PubMed
- Published on 1/30/2024
Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075. PMID: 38290090.
Read At: PubMed
View 380 more publications:View Full Profile at BUMC
News & In the Media
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Published on April 29, 2022
Researchers Pinpoint Blood Biomarker That Foretells Dementia
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Published on February 17, 2022
Loneliness in Older Adults Linked with Three-Fold Increased Dementia Risk
- Published on August 18, 2021
- Published on August 17, 2021
- Published on July 20, 2020
- Published on April 1, 2019
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Published on February 26, 2019
Physical Activity Improves Cognitive and Vascular Health in Older People with Diabetes
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Published on November 15, 2018
News or Noise: Diet Drinks Can Triple Risk of Dementia, Stroke
- Published on November 6, 2018
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Published on November 2, 2018
Can Drinking One Diet Drink a Day Triple the Risk of Dementia and Strokes?
- Published on October 26, 2018
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Published on October 26, 2018
Stress Might Lead to Memory Loss and Brain Shrinkage, Study Says
- Published on October 26, 2018
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Published on October 26, 2018
“Stress Hormone” Cortisol Linked to Early Toll on Thinking Ability
- Published on October 26, 2018
- Published on October 26, 2018
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Published on October 26, 2018
Study Shows Stress Hormone’s Link to Memory Deficits, Brain Shrinkage
- Published on October 26, 2018
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Published on October 26, 2018
People Who Are More Stressed May Have Smaller Brains and Worse Memories, According to a New Study
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Published on October 26, 2018
Stressed Out? Study Suggests It May Affect Memory, Brain Size in Middle Age
- Published on October 26, 2018
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Published on October 26, 2018
It Might Stress You Out to Know What Stress Is Doing to Your Brain
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Published on October 26, 2018
It Might Stress You Out to Know What Stress Is Doing to Your Brain
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Published on October 26, 2018
Stress in Middle Age Found to Shrink Your Brain and Impair Memory
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Published on October 26, 2018
Stress in Middle-Age Can Impair Memory, Reduce Brain Size: Here’s All You Need to Know
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Published on October 26, 2018
Middle Age Stress May Shrink the Brain: Eat These Foods to Fight Stress
- Published on October 26, 2018
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Published on October 26, 2018
High Levels of Stress May Shrink the Brain and Affect Memory
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Published on October 26, 2018
Stress May Be Literally Shrinking Your Brain — Here’s What You Need to Know
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Published on October 26, 2018
New Study Links Stress to Worse Memory, Reduced Brain Size in Middle Age
- Published on May 31, 2017
- Published on August 29, 2016
- Published on May 23, 2016
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Published on April 26, 2016
‘Ideal Cardiovascular Health Index’ Protective Against Dementia
- Published on February 23, 2016